Fzd1 - frizzled class receptor 1 Gene

Mus musculus

Also known as Fz1; FZ-1

Gene ID: 14362 | Gene type: protein coding

About Fzd1

Summary

Enables Wnt-protein binding activity. Involved in astrocyte-dopaminergic neuron signaling; negative regulation of oxidative stress-induced neuron death; and regulation of presynapse assembly. Acts upstream of or within several processes, including Wnt signaling pathway; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface and neuron projection. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human FZD1 (Frizzled class receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Fzd1 Products(1)

mRNA	Protein	Name
NM_021457.3	NP_067432.2	frizzled-1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	15923619	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15923619	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15143170	MGI
acts upstream of or within cell-cell signaling	IDA IDA: Inferred from direct assay	15809042	MGI
acts upstream of or within endothelial cell differentiation	IDA IDA: Inferred from direct assay	15809042	MGI
acts upstream of or within endothelial cell differentiation	IGI IGI: Inferred from genetic interaction	15809042	MGI
acts upstream of or within hard palate development	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within membranous septum morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within muscular septum morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	14627707	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16936075	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14627707	MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21752258	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15143170	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	19883499	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	19883499	MGI
acts upstream of or within ventricular septum morphogenesis	IGI IGI: Inferred from genetic interaction	20940229	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-1

frizzled homolog 1

mFz1

Recombinant Fzd1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70210	Frizzled-1 Protein, Mouse (HEK293, Fc)	O70421 (V69-H248)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9974	Vantictumab	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05176	FZD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd1	NCBI	NCBI:8321

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