Fzd5 - frizzled class receptor 5 Gene

Mus musculus

Also known as Fz5; Fz-5; mFz5; 5330434N09Rik

Gene ID: 14367 | Gene type: protein coding

About Fzd5

Summary

Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; embryonic organ development; and positive regulation of nitrogen compound metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human FZD5 (Frizzled class receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Fzd5 Products(2)

mRNA	Protein	Name
NM_001042659.2	NP_001036124.1	frizzled-5 precursor
NM_022721.4	NP_073558.2	frizzled-5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	18606138	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11520064	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	11265645	MGI
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11092808	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	11092808	MGI
acts upstream of or within apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	18791178	MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	23610556	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11265645	MGI
acts upstream of or within chorionic trophoblast cell differentiation	IMP IMP: Inferred from mutant phenotype	23610556	MGI
acts upstream of or within embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	18791178	MGI
involved in embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	18832390	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	15778706	MGI
acts upstream of or within intestinal epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	15778706	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	11092808	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18791178	MGI
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	15195140	MGI
involved in positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	21857966	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23610556	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	21857966	MGI
acts upstream of or within post-embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	18791178	MGI
involved in post-embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	18832390	MGI
acts upstream of or within regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	23610556	MGI
acts upstream of or within regulation of chorionic trophoblast cell proliferation	IMP IMP: Inferred from mutant phenotype	23610556	MGI
acts upstream of or within syncytiotrophoblast cell differentiation involved in labyrinthine layer development	IMP IMP: Inferred from mutant phenotype	23610556	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	18791178	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11520064	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	23610556	MGI
colocalizes with early endosome	IDA IDA: Inferred from direct assay	16890161	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11520064	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11520064	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-5

frizzled homolog 5

Fzd5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fzd5	Q9EQD0	Gopc	Mus musculus	Q8BH60	Anti Tag CoIP	11520064

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Fzd5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74136	Frizzled-5 Protein, Mouse (CHO, Fc)	Q9EQD0 (A27-P167)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05181	FZD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd5	NCBI	NCBI:7855

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