CSF2RB - colony stimulating factor 2 receptor subunit beta Gene

Homo sapiens

Also known as CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR

Gene ID: 1439 | Gene type: protein coding

About CSF2RB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,913,628-36,940,439 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in appendix (RPKM 40.5), lymph node (RPKM 21.2) and 12 other tissues.

Summary

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

CSF2RB Products(2)

mRNA	Protein	Name
NM_000395.3	NP_000386.1	cytokine receptor common subunit beta isoform 2 precursor
NM_001410827.1	NP_001397756.1	cytokine receptor common subunit beta isoform 1 precursor

CSF2RB Protein Structure

IL6Ra-bind

fn3

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

cytokine receptor common subunit beta

GM-CSF/IL-3/IL-5 receptor common beta subunit

Recombinant CSF2RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73032	EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc)	P19235 (A25-P250)&P32927 (W17-W443)	≥95%
HY-P75608	CD131 Protein, Human (HEK293, His)	P32927 (W17-W443)	≥95%

Related Diseases

Diseases

Alias

Surfactant Metabolism Dysfunction, Pulmonary, 5

SMDP5	Pulmonary Alveolar Proteinosis 5
Pap Due To Csf2rb Deficiency	Csf2rb Deficiency
Pulmonary Surfactant Metabolism Dysfunction 5	Pap5
Surfactant Metabolism Dysfunction, Pulmonary, Type 5

Hereditary Pulmonary Alveolar Proteinosis

Congenital Pap	Congenital Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis, Congenital

Pulmonary Alveolar Proteinosis

Autosomal Dominant Beta Thalassemia

Inclusion Body Beta-Thalassemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03233	CSF2RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CSF2RB	VGNC	VGNC:27756
Macaca mulatta	CSF2RB	VGNC	VGNC:71518
Canis familiaris	CSF2RB	VGNC	VGNC:39656
Rattus norvegicus	CSF2RB	RGD	RGD:620189
Felis catus	CSF2RB	VGNC	VGNC:61216
Others	CSF2RB	NCBI

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