CSF2RB - colony stimulating factor 2 receptor subunit beta Gene

Homo sapiens

Also known as CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR

Gene ID: 1439 | Gene type: protein coding

About CSF2RB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,913,628-36,940,439 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in appendix (RPKM 40.5), lymph node (RPKM 21.2) and 12 other tissues.

Summary

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

CSF2RB Products(2)

mRNA	Protein	Name
NM_000395.3	NP_000386.1	cytokine receptor common subunit beta isoform 2 precursor
NM_001410827.1	NP_001397756.1	cytokine receptor common subunit beta isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	7957082	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1495999	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	18692472	GOA
involved in granulocyte-macrophage colony-stimulating factor signaling pathway	IDA IDA: Inferred from direct assay	18692472	GOA
involved in interleukin-3-mediated signaling pathway	IDA IDA: Inferred from direct assay	8649415	GOA
involved in interleukin-5-mediated signaling pathway	IDA IDA: Inferred from direct assay	1495999	GOA
involved in positive regulation of leukocyte proliferation	IDA IDA: Inferred from direct assay	18692472	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of granulocyte macrophage colony-stimulating factor receptor complex	IDA IDA: Inferred from direct assay	27396825	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	1495999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSF2RB Protein Structure

IL6Ra-bind

fn3

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

cytokine receptor common subunit beta

GM-CSF/IL-3/IL-5 receptor common beta subunit

CSF2RB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSF2RB	P32927	IL5RA	Homo sapiens	Q01344	Saturation Binding	1495999
Intra	CSF2RB	P32927	IL3	Homo sapiens	P08700	Saturation Binding	18692472
Intra	CSF2RB	P32927	IL5	Homo sapiens	P05113	Saturation Binding	1495999
Intra	CSF2RB	P32927	IL5	Homo sapiens	P05113	Crosslink	1495999
Intra	CSF2RB	P32927	JAK2	Homo sapiens	O60674	Anti Bait CoIP	18692472
Intra	CSF2RB	P32927	JAK2	Homo sapiens	O60674	Anti Bait CoIP	16437163
Intra	CSF2RB	P32927	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	20802515

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSF2RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73032	EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc)	P19235 (A25-P250)&P32927 (W17-W443)	≥95%
HY-P75608	CD131 Protein, Human (HEK293, His)	P32927 (W17-W443)	≥95%

Related Diseases

Diseases

Alias

Surfactant Metabolism Dysfunction, Pulmonary, 5

SMDP5	Pulmonary Alveolar Proteinosis 5
Pap Due To Csf2rb Deficiency	Csf2rb Deficiency
Pulmonary Surfactant Metabolism Dysfunction 5	Pap5
Surfactant Metabolism Dysfunction, Pulmonary, Type 5

Hereditary Pulmonary Alveolar Proteinosis

Congenital Pap	Congenital Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis, Congenital

Pulmonary Alveolar Proteinosis

Autosomal Dominant Beta Thalassemia

Inclusion Body Beta-Thalassemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03233	CSF2RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990975	Birinkibart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CSF2RB	VGNC	VGNC:27756
Macaca mulatta	CSF2RB	VGNC	VGNC:71518
Canis familiaris	CSF2RB	VGNC	VGNC:39656
Rattus norvegicus	CSF2RB	RGD	RGD:620189
Felis catus	CSF2RB	VGNC	VGNC:61216
Others	CSF2RB	NCBI

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