2. Gene
  3. KRT80 - keratin 80 Gene

KRT80 - keratin 80 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KB20

Gene ID: 144501 | Gene type: protein coding

About KRT80

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,168,996-52,192,014 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 68 paralogues. Biased expression in skin (RPKM 50.6), esophagus (RPKM 17.5) and 2 other tissues.

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

KRT80 Products(2)

mRNA Protein Name
NM_001081492.2 NP_001074961.1 keratin, type II cytoskeletal 80 isoform K80.1
NM_182507.3 NP_872313.2 keratin, type II cytoskeletal 80 isoform K80
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20843789 GOA
NOT located in desmosome IDA
IDA: Inferred from direct assay
20843789 GOA
located in intermediate filament IDA
IDA: Inferred from direct assay
20843789 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT80 Protein Structure

Filament

Filament: Intermediate filament protein (82 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 80

CK-80

KRT80 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT80 Q6KB66 KRT15 Homo sapiens P19012
Validated Y2H
25416956
Intra
KRT80 Q6KB66 KRT20 Homo sapiens P35900
Y2H Prey Pooling
25416956
Intra
KRT80 Q6KB66 KRT20 Homo sapiens P35900
Validated Y2H
25416956
Intra
KRT80 Q6KB66 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161885 SMARCA2-IN-6 Inhibitor / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-RS07468 KRT80 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KRT80 VGNC VGNC:74138
Rattus norvegicus KRT80 RGD RGD:1359177
Bos taurus KRT80 VGNC VGNC:30742
Canis familiaris KRT80 VGNC VGNC:42534
Mus musculus KRT80 MGD MGI:1921377
Felis catus KRT80 VGNC VGNC:63174