KRT15 - keratin 15 Gene

Homo sapiens

Also known as K15; CK15; K1CO

Gene ID: 3866 | Gene type: protein coding

About KRT15

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,513,745-41,518,890 (from NCBI)

This gene has 9 transcripts (splice variants), 98 orthologues and 68 paralogues. Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]

KRT15 Products(1)

mRNA	Protein	Name
NM_002275.4	NP_002266.3	keratin, type I cytoskeletal 15

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10852826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT15 Protein Structure

Filament

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 15

CK-15

Related Diseases

Diseases

Alias

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Morpheaform Basal Cell Carcinoma

Basal Cell Carcinoma, Morphea	Cicatricial Basal-Cell Carcinoma
Morphea-Type Basal Cell Carcinoma	Morpheic Basal Cell Carcinoma

Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Micronodular Basal Cell Carcinoma

Skin Micronodular Basal Cell Carcinoma

Basal Cell Carcinoma, Micronodular

Malignant Syringoma

Microcystic Adnexal Carcinoma	Microcystic Adnexal Carcinoma Of Skin
Syringomatous Carcinoma	Eccrine Epithelioma

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Breast Fibroadenoma

Fibroadenoma	Fibroadenoma Of Breast
Juvenile Fibroadenoma Of Breast	Cellular Fibroadenoma
Complex Fibroadenoma Of Breast	Juvenile Fibroadenoma
Fibroadenoma Nos	Fibroadenoma Unspecified Site

Adenoid Basal Cell Carcinoma

Skin Adenoid Basal Cell Carcinoma

Basal Cell Carcinoma - Adenoid

Epidermolysis Bullosa Simplex

Ebs	Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Pilar Sheath Acanthoma

Acanthoma, Pilar Sheath

Epidermolysis Bullosa

Acantholysis Bullosa

Kindler Syndrome

Poikiloderma Of Kindler	Bullous Acrokeratotic Poikiloderma Of Kindler And Weary
Congenital Bullous Poikiloderma	KNDLRS
Poikiloderma, Hereditary Acrokeratotic	Poikiloderma, Congenital, With Bullae, Weary Type
Kindler'S Syndrome	Poikiloderma Congenital With Bullae Weary Type
Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary	Hereditary Acrokeratotic Poikiloderma
Weary Syndrome	Poikiloderma Hereditary Acrokeratotic
Potassium Deficiency

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Follicular Infundibulum Tumor

Tumor Of Follicular Infundibulum	Follicular Infundibulum Tumour
Neoplasm Of The Follicular Infundibulum	Tumour Of Follicular Infundibulum

Fibroepithelial Basal Cell Carcinoma

Fibroepithelioma Of Pinkus	Fibroepithelioma Of Pinkus Type
Pinkus Tumor

Sweat Gland Cancer

Sweat Gland Carcinoma	Malignant Neoplasm Of Sweat Gland
Malignant Tumor Of The Sweat Gland	Carcinoma Of The Sweat Gland
Primary Malignant Neoplasm Of Sweat Gland	Sweat Gland Neoplasms

Alopecia

Epithelioid Sarcoma

Epithelioid Cell Sarcoma	Sarcoma Epithelioid
Sarcoma, Epithelioid

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Syringocystadenoma Papilliferum

Fistulous Vegetative Verrucous Hydradenoma	Papillary Syringadenoma
Naevus Syringocystadenomatosus Papilliferus	Papillary Syringocystadenoma
Scap	Syringadenoma Papilliferum
Papillary Hidradenoma

Spiradenoma

Eccrine Spiradenoma	Benign Eccrine Spiradenoma
Eccrine Spiradenoma Of Skin	Es
Eccrine Spiradenoma, Benign

Hidrocystoma

Apocrine Cystadenoma	Eccrine Hidrocystoma
Eccrine Cystadenoma	Eccrine Hidrocystoma Of Skin
Apocrine Adenoma

Cystic Basal Cell Carcinoma

Skin Cystic Basal Cell Carcinoma

Conjunctival Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Conjunctiva	Conjunctival Epidermoid Carcinoma
Invasive Squamous Cell Carcinoma Of The Conjunctiva	Ocular Surface Squamous Neoplasia

Epidermal Appendage Tumor

Neoplasm Of Skin With Adnexal Differentiation	Neoplasm Of The Skin Appendage
Skin Appendage Tumour

Basosquamous Carcinoma

Carcinoma, Basosquamous	Basisquamous Cell Carcinoma
Basosquamous Cell Carcinoma	Metatypical Carcinoma

Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm

Necrotizing Sialometaplasia

Sialometaplasia, Necrotizing

Sebaceous Gland Neoplasm

Sebaceous Gland Neoplasms

Sebaceous Neoplasm

Hair Disease

Hair Diseases	Hair Anomaly
Hair Disorder	Hair Problems

Squamous Papillomatosis

Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular	Circumscribed Solid Basal Cell Carcinoma
Skin Nodulo-Ulcerative Basal Cell Carcinoma	Skin Solid Basal Cell Carcinoma
Skin Nodular Basal Cell Carcinoma	Skin Nodular Solid Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Circumscribed Solid Basal Cell Carcinoma Of Skin

Sebaceous Adenoma

Adenoma Of The Sebaceous Gland

Skin Appendage Sebaceous Adenoma

Follicular Mucinosis

Alopecia Mucinosa

Mucinosis, Follicular

Hidradenoma

Adenoma, Sweat Gland	Hidradenoma Of Skin
Sweat Gland Adenoma	Syringoadenoma
Eccrine Acrospiroma	Benign Neoplasm Of Sweat Gland

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Eccrine Porocarcinoma

Porocarcinoma	Eccrine Porocarcinoma Of Skin
Malignant Eccrine Poroma

Psoriasis

Sweat Gland Disease

Sweat Gland Diseases

Skin Papilloma

Cutaneous Papilloma	Papilloma Of Skin
Papilloma Skin

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Recessive Dystrophic Epidermolysis Bullosa

Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis	Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type
Rdeb, Hallopeau-Siemens Type	Severe Generalized Rdeb
Severe Generalized Recessive Dystrophic Epidermolysis Bullosa	Rdeb Generalisata Gravis
Rdeb, Severe Generalized	Rdeb-Sev Gen
Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized	Hallopeau-Siemens Disease

Aniridia 1

Aniridia	Congenital Aniridia
AN1	An
Cataract With Late-Onset Corneal Dystrophy	Aplasia Of Iris
Absent Iris	Irideremia
Aniridia Ii, Formerly	An2, Formerly
An2	Aniridia Type Ii
Aniridia, Type 1	An-1
Absence Of Iris	Agenesis Of Iris
Congenital Absence Of Iris	Hereditary Aniridia
Sporadic Aniridia

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07438	KRT15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KRT15	VGNC	VGNC:50396
Canis familiaris	KRT15	VGNC	VGNC:42518
Macaca mulatta	KRT15	VGNC	VGNC:74209
Rattus norvegicus	KRT15	RGD	RGD:1303044
Mus musculus	KRT15	MGD	MGI:96689