2. Gene
  3. FBXL14 - F-box and leucine rich repeat protein 14 Gene

FBXL14 - F-box and leucine rich repeat protein 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Fbl14

Gene ID: 144699 | Gene type: protein coding

About FBXL14

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:1,565,993-1,594,842 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 15 paralogues. Ubiquitous expression in testis (RPKM 7.1), colon (RPKM 6.6) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL14 Products(4)

mRNA Protein Name
NM_001405291.1 NP_001392220.1 F-box/LRR-repeat protein 14 isoform 2
NM_001405292.1 NP_001392221.1 F-box/LRR-repeat protein 14 isoform 3
NM_001405293.1 NP_001392222.1 F-box/LRR-repeat protein 14 isoform 4
NM_152441.3 NP_689654.1 F-box/LRR-repeat protein 14 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19955572 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19955572 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19955572 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19955572 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL14 Protein Structure

F-box-like

F-box-like: F-box-like (10 - 46)

LRR_6

LRR_6: Leucine Rich repeat (91 - 108)

LRR_6

LRR_6: Leucine Rich repeat (168 - 191)

LRR_6

LRR_6: Leucine Rich repeat (230 - 250)

LRR_6

LRR_6: Leucine Rich repeat (254 - 275)

LRR_2

LRR_2: Leucine Rich Repeat (307 - 322)

LRR_6

LRR_6: Leucine Rich repeat (332 - 352)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 14

FBXL14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXL14 Q8N1E6 SKP1 Homo sapiens P63208
Anti Tag CoIP
28514442
Intra
FBXL14 Q8N1E6 SKP1 Homo sapiens P63208
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04784 FBXL14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FBXL14 VGNC VGNC:54946
Macaca mulatta FBXL14 VGNC VGNC:81404
Felis catus FBXL14 VGNC VGNC:83880
Bos taurus FBXL14 VGNC VGNC:28890
Mus musculus FBXL14 MGD MGI:2141676
Rattus norvegicus FBXL14 RGD RGD:1305523