2. Gene
  3. FBXL14 - F-box and leucine rich repeat protein 14 Gene

FBXL14 - F-box and leucine rich repeat protein 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Fbl14

Gene ID: 144699 | Gene type: protein coding

About FBXL14

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:1,565,993-1,594,842 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 15 paralogues. Ubiquitous expression in testis (RPKM 7.1), colon (RPKM 6.6) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL14 Products(4)

mRNA Protein Name
NM_001405291.1 NP_001392220.1 F-box/LRR-repeat protein 14 isoform 2
NM_001405292.1 NP_001392221.1 F-box/LRR-repeat protein 14 isoform 3
NM_001405293.1 NP_001392222.1 F-box/LRR-repeat protein 14 isoform 4
NM_152441.3 NP_689654.1 F-box/LRR-repeat protein 14 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19955572 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19955572 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19955572 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19955572 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL14 Protein Structure

F-box-like

F-box-like: F-box-like (10 - 46)

LRR_6

LRR_6: Leucine Rich repeat (91 - 108)

LRR_6

LRR_6: Leucine Rich repeat (168 - 191)

LRR_6

LRR_6: Leucine Rich repeat (230 - 250)

LRR_6

LRR_6: Leucine Rich repeat (254 - 275)

LRR_2

LRR_2: Leucine Rich Repeat (307 - 322)

LRR_6

LRR_6: Leucine Rich repeat (332 - 352)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 14

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04784 FBXL14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FBXL14 VGNC VGNC:54946
Macaca mulatta FBXL14 VGNC VGNC:81404
Felis catus FBXL14 VGNC VGNC:83880
Bos taurus FBXL14 VGNC VGNC:28890
Mus musculus FBXL14 MGD MGI:2141676
Rattus norvegicus FBXL14 RGD RGD:1305523