Gfra3 - glial cell line derived neurotrophic factor family receptor alpha 3 Gene

Mus musculus

Also known as GFRalpha3

Gene ID: 14587 | Gene type: protein coding

About Gfra3

Summary

This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand Artemin to the RET receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]

Gfra3 Products(1)

mRNA	Protein	Name
NM_010280.4	NP_034410.3	GDNF family receptor alpha-3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables axon guidance receptor activity	IMP IMP: Inferred from mutant phenotype	12160745	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9452475	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	10482239	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	10482239	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	10482239	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	10482239	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9452475	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GDNF family receptor alpha-3

GDNFR-alpha-3

GFR alpha-3

Recombinant Gfra3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76951	GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc)	O35118 (N29-R379)	≥95%
HY-P76952	GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His)	O35118 (N29-R379)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05388	GFRA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99748	Nadecnemab	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gfra3	NCBI	NCBI:2676

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