2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. GFR-alpha-3
  7. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His)

GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His)

Cat. No.: HY-P76952
Handling Instructions

GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.
Background

The GFRA3/GDNFR-alpha-3 Protein serves as a receptor for the glial cell line-derived neurotrophic factor, artemin, facilitating artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. The protein interacts with SORL1, suggesting potential involvement in signaling cascades associated with neurotrophic responses.
Species

Mouse
Source

HEK293
Tag

C-His
Accession

O35118 (N29-R379)
Gene ID
Molecular Construction
N-term
GFRA3/GDNFR-alpha-3 (N29-R379)
Accession # O35118
His
C-term
Synonyms
GDNF family receptor alpha-3; GFR-alpha-3
Molecular Weight

42-52 kDa
Purity

Greater than 85% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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