2. Gene
  3. IL34 - interleukin 34 Gene

IL34 - interleukin 34 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IL-34; C16orf77

Gene ID: 146433 | Gene type: protein coding

About IL34

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,579,899-70,660,682 (from NCBI)

This gene has 5 transcripts (splice variants) and 91 orthologues. Biased expression in spleen (RPKM 59.9), skin (RPKM 16.8) and 5 other tissues.

Summary

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

IL34 Products(9)

mRNA Protein Name
NM_001172771.2 NP_001166242.1 interleukin-34 isoform 2 precursor
NM_001172772.2 NP_001166243.1 interleukin-34 isoform 1 precursor
NM_001393493.1 NP_001380422.1 interleukin-34 isoform 1 precursor
NM_001393494.1 NP_001380423.1 interleukin-34 isoform 1 precursor
NM_001393495.1 NP_001380424.1 interleukin-34 isoform 2 precursor
NM_001393496.1 NP_001380425.1 interleukin-34 isoform 2 precursor
NM_001393497.1 NP_001380426.1 interleukin-34 isoform 3
NM_001393498.1 NP_001380427.1 interleukin-34 isoform 4
NM_152456.3 NP_689669.2 interleukin-34 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22483114 GOA
enables macrophage colony-stimulating factor receptor binding IDA
IDA: Inferred from direct assay
18467591 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22483114 GOA
Biological Process GO Annotation Evidence Reference Source
involved in interleukin-34-mediated signaling pathway IDA
IDA: Inferred from direct assay
26754294 GOA
acts upstream of or within positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18467591 GOA
acts upstream of positive regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
23409120 GOA
acts upstream of positive regulation of macrophage proliferation IDA
IDA: Inferred from direct assay
26754294 GOA
involved in positive regulation of monocyte differentiation IDA
IDA: Inferred from direct assay
23409120 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18467591 GOA
acts upstream of or within positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
26754294 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
18467591 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL34 Protein Structure

IL34

IL34: Interleukin 34 (24 - 185)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

interleukin-34

Recombinant IL34 Proteins

Cat. No. Product Name Accession Purity
HY-P73211 IL-34 Protein, Human (CHO, His) Q6ZMJ4-1/AAH29804.1 (N21-P242) ≥95%
HY-P700125AF Animal-Free IL-34 Protein, Human (His) Q6ZMJ4-1 (N21-P242) ≥95%

Related Diseases

Diseases Alias
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids

Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Alsp

Gpsc

Subcortical Gliosis Of Neumann

Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1

Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids

Hdls

HDLS1

Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia

Gliosis, Familial Progressive Subcortical

Leukoencephalopathy, Diffuse Hereditary, With Spheroids

Pold

Pigmentary Orthochromatic Leukodystrophy

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Familial Progressive Subcortical Gliosis

Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant

Dementia, Familial, Neumann Type

Adult-Onset Leukodystrophy With Neuroaxonal Spheroids

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids

Neuroaxonal Leukodystrophy

Fpsg

Familial Dementia, Neumann Type

Familial Dementia Neumann Type

Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath

Giant Cell Tumor Of Tendon Sheath

Giant Cell Tumor Of Tenosynovium

Giant Cell Tumour Of Tendon Sheath

Giant Cell Tumour Of Tenosynovium

Tenosynovial Giant Cell Tumour

Diffuse-Type Gct

Diffuse-Type Giant Cell Tumor

Pigmented Villonodular Synovitis

Tgct

Tsgct
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
Pigmented Villonodular Synovitis

Diffuse Giant Cell Tumor Of Tenosynovium

Villous Tenosynovitis

Diffuse Pigmented Villonodular Synovitis

Diffuse-Type Gct

Diffuse-Type Giant Cell Tumor

Localized Pigmented Villonodular Synovitis

Tgct

Tsgct

Tenosynovial Giant Cell Tumor

Tenosynovial Giant Cell Tumors

Synovitis Pigmented Villonodular

Synovitis, Pigmented Villonodular

Fibrous Histiocytoma Of Tendon Sheath

Testicular Germ Cell Tumor

Chronic Haemorrhagic Villous Synovitis

Pvns - [Pigmented Villonodular Synovitis]

Villonodular Synovitis
Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma
Peripheral Nerve Schwannoma
Chronic Apical Periodontitis

Apical Periodontitis Nos

Apex Periodontitis

Periapical Infection Nos
Bone Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06758 IL34 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL34 MGD MGI:1923777
Macaca mulatta IL34 VGNC VGNC:73669
Rattus norvegicus IL34 RGD RGD:1586038
Bos taurus IL34 VGNC VGNC:30156
Canis familiaris IL34 VGNC VGNC:41983
Felis catus IL34 VGNC VGNC:62913
Others IL34 NCBI