Gls - glutaminase Gene

Mus musculus

Also known as 6330442B14; B230365M23Rik

Gene ID: 14660 | Gene type: protein coding

About Gls

Chromosome 1: 52,202,607-52,272,391 reverse strand.GRCm39:CM000994.3

This gene has 17 transcripts (splice variants), 305 orthologues, 1 paralogue and is associated with 7 phenotypes. Broad expression in CNS E18 (RPKM 2.), cortex adult (RPKM 19.9) and 26 other tissues.

Summary

Enables Glutaminase activity and identical protein binding activity. Involved in glutamate biosynthetic process; glutamine catabolic process; and protein homotetramerization. Acts upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (Glutaminase). [provided by Alliance of Genome Resources, Apr 2022]

Gls Products(2)

mRNA	Protein	Name
NM_001113383.1	NP_001106854.1	glutaminase kidney isoform, mitochondrial isoform 2
NM_001081081.2	NP_001074550.1	glutaminase kidney isoform, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutaminase activity	IDA IDA: Inferred from direct assay	22228304	MGI
enables glutaminase activity	IMP IMP: Inferred from mutant phenotype	16641247	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22228304	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16899818	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16641247	MGI
involved in glutamate biosynthetic process	IDA IDA: Inferred from direct assay	22228304	MGI
involved in glutamine catabolic process	IDA IDA: Inferred from direct assay	22228304	MGI
acts upstream of or within glutamine catabolic process	IMP IMP: Inferred from mutant phenotype	16641247	MGI
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	22228304	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	16641247	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	16641247	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gls Protein Structure

EF-hand_14

Glutaminase

ANK

Ank_2

ANK

0
200
400
600
674 a.a.

Protein Preferred Names

Protein Names

glutaminase kidney isoform, mitochondrial

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12248	Telaglenastat		99.82%	Phase 2
HY-108917	Morphothiadin	Inhibitor	99.84%	Phase 2
HY-128357	Ibezapolstat	Inhibitor	≥98.0%	Phase 2
HY-P2760	Glutaminase		/	Phase 2
HY-12248A	Telaglenastat hydrochloride		/	Phase 2
HY-103671	IPN60090	Inhibitor	99.47%	Phase 1
HY-103671A	IPN60090 dihydrochloride	Inhibitor	99.68%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99109	Zimberelimab	Inhibitor	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-79583	Glutaminase-IN-3	Inhibitor	98.47%	Unkown
HY-144666	GLS-1-IN-1	Inhibitor	99.64%	Unkown
HY-151434	GLS1 Inhibitor-6		/	Unkown
HY-128357A	Ibezapolstat hydrochloride	Inhibitor	/	Unkown
HY-136704	GLS1 Inhibitor-1	Inhibitor	/	Unkown
HY-146616	GLS1 Inhibitor-3	Inhibitor	/	Unkown
HY-146617	GLS1 Inhibitor-4		/	Unkown
HY-146658	Glutaminase-IN-4	Inhibitor	/	Unkown
HY-148241	A-446	Inhibitor	/	Unkown
HY-152207	LWG-301		/	Unkown
HY-155138	GLS1 Inhibitor-7	Inhibitor	/	Unkown
HY-RS05500	GLS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05501	Gls Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05502	Gls Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05503	GLS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gls	NCBI	NCBI:2744

Name
Email *

	Sorry, but the email address you supplied was invalid.