2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. Glutaminase-IN-3

Glutaminase-IN-3 (compound 657) is a potent glutaminase inhibitor with an IC50 of 0.24 μM for Glutaminase 1 (GLS1). Glutaminase-IN-3 is extracted from patent WO2014089048A1, compound 657.

For research use only. We do not sell to patients.

Glutaminase-IN-3 Chemical Structure

Glutaminase-IN-3 Chemical Structure

CAS No. : 1439399-45-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 In-stock
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
50 mg USD 250 In-stock
100 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

Glutaminase-IN-3 Related Antibodies

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1 Publications Citing Use of MCE Glutaminase-IN-3

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Description

Glutaminase-IN-3 (compound 657) is a potent glutaminase inhibitor with an IC50 of 0.24 μM for Glutaminase 1 (GLS1). Glutaminase-IN-3 is extracted from patent WO2014089048A1, compound 657[1].

Molecular Weight

452.45

Formula

C19H19F3N6O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=NN=C(CCCCC3=NN=C(N)S3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (110.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2102 mL 11.0509 mL 22.1019 mL
5 mM 0.4420 mL 2.2102 mL 4.4204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2102 mL 11.0509 mL 22.1019 mL 55.2547 mL
5 mM 0.4420 mL 2.2102 mL 4.4204 mL 11.0509 mL
10 mM 0.2210 mL 1.1051 mL 2.2102 mL 5.5255 mL
15 mM 0.1473 mL 0.7367 mL 1.4735 mL 3.6836 mL
20 mM 0.1105 mL 0.5525 mL 1.1051 mL 2.7627 mL
25 mM 0.0884 mL 0.4420 mL 0.8841 mL 2.2102 mL
30 mM 0.0737 mL 0.3684 mL 0.7367 mL 1.8418 mL
40 mM 0.0553 mL 0.2763 mL 0.5525 mL 1.3814 mL
50 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1051 mL
60 mM 0.0368 mL 0.1842 mL 0.3684 mL 0.9209 mL
80 mM 0.0276 mL 0.1381 mL 0.2763 mL 0.6907 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5525 mL
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Glutaminase-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glutaminase-IN-31439399-45-7GlutaminaseInhibitorinhibitorinhibit

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