CST2 - cystatin SA Gene

Homo sapiens

Gene ID: 1470 | Gene type: protein coding

About CST2

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,823,769-23,826,729 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues and 11 paralogues. Restricted expression toward salivary gland (RPKM 1475.8).

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

CST2 Products(1)

mRNA	Protein	Name
NM_001322.3	NP_001313.1	cystatin-SA precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	24248522	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24248522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cystatin-SA

cystatin 2

CST2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CST2	P09228	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	CST2	P09228	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	CST2	P09228	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CST2	P09228	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CST2	P09228	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CST2	P09228	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	CST2	P09228	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CST2	P09228	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	CST2	P09228	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	CST2	P09228	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CST2	P09228	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CST2	P09228	P4HB	Homo sapiens	P07237	Y2H Prey Pooling	32296183
Intra	CST2	P09228	P4HB	Homo sapiens	P07237	Y2H Array	32296183
Intra	CST2	P09228	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	CST2	P09228	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	CST2	P09228	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	CST2	P09228	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CST2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7891	Cystatin SA/CST2 Protein, Human (HEK293, His)	P09228 (W21-A141)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03263	CST2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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