KRT25 - keratin 25 Gene

Homo sapiens

Also known as ARWH3; KRT25A; KRT24IRS1

Gene ID: 147183 | Gene type: protein coding

About KRT25

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,748,021-40,755,542 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues, 68 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

KRT25 Products(1)

mRNA	Protein	Name
NM_181534.4	NP_853512.1	keratin, type I cytoskeletal 25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26902920	GOA
enables protein heterodimerization activity	IMP IMP: Inferred from mutant phenotype	28899683	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	26902920	GOA
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in keratin filament	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT25 Protein Structure

Filament

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 25

CK-25

KRT25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT25	Q7Z3Z0	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	32296183
Intra	KRT25	Q7Z3Z0	KRT78	Homo sapiens	Q8N1N4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Woolly Hair, Autosomal Recessive 3

ARWH3	Woolly Hair, Autosomal Recessive 3, With Hypotrichosis
Autosomal Recessive Woolly Hair 3	Woolly Hair Autosomal Recessive 3

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Hypotrichosis

Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis	HYPT7
Hypotrichosis, Localized, Autosomal Recessive 2	Lah2
Ah	Total Hypotrichosis, Mari Type
Wh/Ht	Hypotrichosis, Autosomal Recessive
Hypotrichosis, Total, Mari Type	Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis
Total Mari Type Hypotrichosis	Alopecia Universalis Congenita, Mari Type
Mari Type Alopecia Universalis Congenita	Autosomal Recessive Hypotrichosis
Autosomal Recessive Localized Hypotrichosis	Autosomal Recessive Woolly Hair With Or Without Hypotrichosis
Htl	Hypotrichoses
Hypotrichosis	Lah
Alopecia Universalis Congenita Mari Type	Hypotrichosis Autosomal Recessive
Hypotrichosis Localized Autosomal Recessive 2	Total Hypotrichosis Mari Type
Woolly Hair Autosomal Recessive 2	ARWH2
Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Combined Oxidative Phosphorylation Deficiency 16

COXPD16	Infantile Hypertrophic Cardiomyopathy Due To Mrpl44 Deficiency
Combined Oxidative Phosphorylation Defect Type 16	Combined Oxidative Phosphorylation Deficiency, Type 16

Woolly Hair, Autosomal Dominant

Autosomal Dominant Woolly Hair	ADWH
Woolly Hair Autosomal Dominant

Naegeli-Franceschetti-Jadassohn Syndrome

Naegeli Syndrome	Nfj Syndrome
NFJS	Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy
Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis	Dpr
Franceschetti-Jadassohn Syndrome	Nfjs/Dpr

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Steatocystoma Multiplex

Sebocystomatosis	Multiple Sebaceous Cysts
Multiplex Steatocystoma	Sebaceous Cysts, Multiple
SM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07449	KRT25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT25	RGD	RGD:1359097
Felis catus	KRT25	VGNC	VGNC:108194
Mus musculus	KRT25	MGD	MGI:1918060
Macaca mulatta	KRT25	VGNC	VGNC:74167
Bos taurus	KRT25	VGNC	VGNC:30724
Canis familiaris	KRT25	VGNC	VGNC:49880

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