KRT78 - keratin 78 Gene

Homo sapiens

Also known as K5B; K78; Kb40; CK-78

Gene ID: 196374 | Gene type: protein coding

About KRT78

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,837,804-52,848,994 (from NCBI)

This gene has 5 transcripts (splice variants), 84 orthologues and 68 paralogues. Restricted expression toward esophagus (RPKM 278.9).

Summary

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]

KRT78 Products(2)

mRNA	Protein	Name
NM_001300814.1	NP_001287743.1	keratin, type II cytoskeletal 78 isoform 2
NM_173352.4	NP_775487.2	keratin, type II cytoskeletal 78 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT78 Protein Structure

Filament

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

keratin, type II cytoskeletal 78

cytokeratin-78

KRT78 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT78	Q8N1N4	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT35	Homo sapiens	Q92764	MAPPIT	32296183
Intra	KRT78	Q8N1N4	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT35	Homo sapiens	Q92764	Complementation	32296183
Intra	KRT78	Q8N1N4	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT78	Q8N1N4	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT78	Q8N1N4	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	KRT78	Q8N1N4	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT78	Q8N1N4	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT78	Q8N1N4	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fiedler'S Myocarditis

Isolated Myocarditis	Fiedler Myocarditis
Idiopathic Myocarditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07465	KRT78 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KRT78	VGNC	VGNC:30740
Felis catus	KRT78	VGNC	VGNC:63172
Canis familiaris	KRT78	VGNC	VGNC:42532
Rattus norvegicus	KRT78	RGD	RGD:1591341
Macaca mulatta	KRT78	VGNC	VGNC:74146
Mus musculus	KRT78	MGD	MGI:1917529

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