S1pr2 - sphingosine-1-phosphate receptor 2 Gene

Mus musculus

Also known as Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik

Gene ID: 14739 | Gene type: protein coding

About S1pr2

Chromosome 9: 20,873,657-20,888,077 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 56 phenotypes. Broad expression in lung adult (RPKM 19.6), limb E14.5 (RPKM 17.) and 24 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 Products(1)

mRNA	Protein	Name
NM_010333.4	NP_034463.2	sphingosine 1-phosphate receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24453941	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	11553273	MGI
acts upstream of or within negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	11553273	MGI
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	23106337	MGI
involved in regulation of postsynapse assembly	EXP EXP: Inferred from Experiment	26748478	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	26748478	MGI
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23106337	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	26748478	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26748478	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	35781853	MGI
is active in presynapse	IEP IEP: Inferred from expression pattern	35781853	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr2 Protein Structure

7tm_GPCRs

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 2

G-protein coupled receptor 13	S1P receptor 2
S1P receptor Edg-5	endothelial differentiation G-protein coupled receptor 5
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5	lysophospholipid receptor B2
sphingosine 1-phosphate receptor Edg-5	sphingosine-1-phosphate receptor S1P(2)

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139310	GLPG2938	Antagonist	99.93%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr2	NCBI	NCBI:9294

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