S1PR2 - sphingosine-1-phosphate receptor 2 Gene

Homo sapiens

Also known as EDG5; H218; LPB2; S1P2; AGR16; EDG-5; DFNB68; Gpcr13

Gene ID: 9294 | Gene type: protein coding

About S1PR2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,221,433-10,231,331 (from NCBI)

This gene has 1 transcript (splice variant), 192 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 10.4), lymph node (RPKM 5.1) and 22 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

S1PR2 Products(1)

mRNA	Protein	Name
NM_004230.4	NP_004221.3	sphingosine 1-phosphate receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled peptide receptor activity	IPI IPI: Inferred from physical interaction	29453251	GOA
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	24851274	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	24851274	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24453941	GOA
enables sphingosine-1-phosphate receptor activity	IDA IDA: Inferred from direct assay	29453251	GOA
enables sphingosine-1-phosphate receptor activity	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	29453251	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	24851274	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24851274	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR2 Protein Structure

7tm_1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 2

CTD-2369P2.2	S1P receptor 2
S1P receptor EDG5	S1P receptor Edg-5
deafness, autosomal recessive 68	endothelial differentiation G-protein coupled receptor 5
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5	sphingosine 1-phosphate receptor Edg-5

S1PR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S1PR2	O95136	ITGB4	Homo sapiens	P16144	Anti Bait CoIP	24851274

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pulmonary Edema

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Hearing Loss Disorder
Hearing Loss, Sensorineural	Central Hearing Loss
High Frequency Deafness	High Frequency Hearing Loss
High-Frequency Hearing Loss	Perceptive Deafness
Perceptive Hearing Loss	Perceptive Hearing Loss Or Deafness
Sensorineural Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Deafness, Autosomal Recessive 68

DFNB68	Autosomal Recessive Nonsyndromic Deafness 68
Autosomal Recessive Deafness 68	Deafness, Autosomal Recessive, 68
Deafness, Autosomal Recessive, Type 68

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139310	GLPG2938	Antagonist	99.93%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S1PR2	RGD	RGD:68334
Felis catus	S1PR2	VGNC	VGNC:64846
Mus musculus	S1PR2	MGD	MGI:99569
Macaca mulatta	S1PR2	VGNC	VGNC:77144
Canis familiaris	S1PR2	VGNC	VGNC:108257
Bos taurus	S1PR2	VGNC	VGNC:34253

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