ZNF582 - zinc finger protein 582 Gene

Homo sapiens

Gene ID: 147948 | Gene type: protein coding

About ZNF582

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,382,751-56,393,534 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 62 paralogues. Ubiquitous expression in thyroid (RPKM 2.0), testis (RPKM 2.0) and 25 other tissues.

Summary

The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ZNF582 Products(2)

mRNA	Protein	Name
NM_001320371.4	NP_001307300.2	zinc finger protein 582
NM_144690.3	NP_653291.1	zinc finger protein 582

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF582 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 582

ZNF582 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF582	Q96NG8	NECTIN4	Homo sapiens	Q96NY8	Anti Tag CoIP	33961781
Intra	ZNF582	Q96NG8	NECTIN4	Homo sapiens	Q96NY8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anal Squamous Cell Carcinoma

Epidermoid Anal Carcinoma

Carcinoma Of Anal Margin

Chronic Cervicitis

Vulva Cancer

Vulvar Carcinoma	Malignant Neoplasm Of Vulva
Vulva Carcinoma	Carcinoma Of Vulva
Vulvar Cancer	Vulval Cancer
Vulvar Neoplasms	Ca Vulva
Malignant Tumor Of Vulva	Malignant Vulvar Tumor
Neoplasm Of Vulva	Vulval Neoplasm
Vulvar Neoplasm	Vulvar Tumor
Cancer Of Vulva	Malignant Tumour Of Vulva

Uterus Carcinoma In Situ

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix	Carcinoma In Situ Of Uterine Cervix
Cervical Intraepithelial Neoplasia	Carcinoma Of Cervix Stage 0
Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia	Cervix Ca In Situ
Cin Iii	Cin Iii - Carcinoma In Situ Of Cervix
Cin Iii - Severe Dyskaryosis	Severe Dysplasia Of Cervix
Severe Dysplasia Of The Cervix Uteri	Squamous Intraepithelial Neoplasia, Grade Iii
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Vulva Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Vulva	Vulvar Squamous Cell Carcinoma
Vulvar Epidermoid Carcinoma	Squamous Cell Carcinoma Of The Vulva

Anus Cancer

Anal Cancer	Anal Carcinoma
Malignant Anal Tumor	Cancer Of The Anus
Malignant Neoplasm Of Anus	Anus Neoplasms

Cervicitis

Uterine Cervicitis

Inflammation Of Cervix

Anus Disease

Anal Fissure	Ulcer Of Anus
Anus Diseases	Anal Disease
Anal Fissure And Fistula	Anal Ulcer
Fissure In Ano	Nontraumatic Tear Of Anus
Solitary Anal Ulcer	Abnormality Of The Anus
Anal Disorders	Ulcer Of Anus And Rectum
Solitary Ulcer Of Anus	Stercoral Ulcer Of Anus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16154	ZNF582 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF582	RGD	RGD:7617005
Mus musculus	ZNF582	MGD	MGI:3782026
Macaca mulatta	ZNF582	VGNC	VGNC:79608
Canis familiaris	ZNF582	VGNC	VGNC:48766

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