2. Gene
  3. Cxcl1 - chemokine (C-X-C motif) ligand 1 Gene

Cxcl1 - chemokine (C-X-C motif) ligand 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1

Gene ID: 14825 | Gene type: protein coding

About Cxcl1

Summary

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]

Cxcl1 Products(1)

mRNA Protein Name
NM_008176.3 NP_032202.1 growth-regulated alpha protein precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
30294880 MGI
involved in positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
10725737 MGI
involved in positive regulation of neutrophil mediated killing of fungus IDA
IDA: Inferred from direct assay
10725737 MGI
involved in positive regulation of superoxide anion generation IDA
IDA: Inferred from direct assay
10725737 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
10725737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth-regulated alpha protein

C-X-C motif chemokine 1

GRO1 oncogene

KC/GR)-alpha

KC/GRO-alpha

alpha-chemokine

platelet-derived growth factor-inducible protein KC

secretory protein N51

Recombinant Cxcl1 Proteins

Cat. No. Product Name Accession Purity
HY-P7186 GRO-alpha/CXCL1 Protein, Mouse (CHO) P12850 (A25-K96) ≥95%
HY-P7188 GRO-alpha/CXCL1 Protein, Mouse P12850 (A25-K96) ≥95%
HY-P72684 GRO-alpha/CXCL1 Protein, Mouse (HEK293, His) P12850 (R20-K96) ≥95%
HY-P700167AF Animal-Free GRO-alpha/CXCL1 Protein, Mouse (His) P12850 (N29-K96) ≥95%
HY-P700559 GRO-alpha/CXCL1 Protein, Mouse (His) P12850 (N29-K96) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115644 BMS-470539 dihydrochloride Agonist 99.95% Unkown
HY-12927 SX-517 Antagonist 99.88% Unkown
HY-163475 CXCL-CXCR1/2-IN-1 Inhibitor 99.64% Unkown
HY-N2573 Corydalmine Inhibitor / Unkown
HY-N2573A Corydalmine hydrochloride Inhibitor / Unkown
HY-RS03383 CXCL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl1 NCBI NCBI:2919
Canis familiaris Cxcl1 NCBI
Macaca fascicularis Cxcl1 NCBI NCBI:102126138
Susscrofa domestica Cxcl1 NCBI
Rattus norvegicus Cxcl1 NCBI NCBI:81503
Macaca mulatta Cxcl1 NCBI NCBI:574222