DIRAS1 - DIRAS family GTPase 1 Gene

Homo sapiens

Also known as RIG; GBTS1; Di-Ras1

Gene ID: 148252 | Gene type: protein coding

About DIRAS1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,714,567-2,721,372 (from NCBI)

This gene has 3 transcripts (splice variants), 247 orthologues and 35 paralogues. Biased expression in brain (RPKM 26.6), heart (RPKM 24.7) and 6 other tissues.

Summary

DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

DIRAS1 Products(1)

mRNA	Protein	Name
NM_145173.4	NP_660156.1	GTP-binding protein Di-Ras1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	12194967	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	12194967	GOA
NOT enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	12194967	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12194967	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12194967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIRAS1 Protein Structure

Ras

0
100
198 a.a.

Protein Preferred Names

Protein Names

GTP-binding protein Di-Ras1

DIRAS family, GTP-binding RAS-like 1

DIRAS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DIRAS1	O95057	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	DIRAS1	O95057	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	DIRAS1	O95057	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	DIRAS1	O95057	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	DIRAS1	O95057	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	DIRAS1	O95057	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	DIRAS1	O95057	RAP1GDS1	Homo sapiens	P52306-5	Validated Y2H	32296183
Intra	DIRAS1	O95057	UNC13B	Homo sapiens	O14795	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Photosensitive Epilepsy

Pse	Photogenic Epilepsy
Photoparoxysmal Response	Reflex Epilepsy, Photosensitive
Photoparoxysmal Response 1

Esophageal Basaloid Squamous Cell Carcinoma

Basaloid Squamous Carcinoma Of Esophagus

Esophageal Basaloid Carcinoma

Sciatic Neuropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03775	DIRAS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DIRAS1	VGNC	VGNC:61497
Bos taurus	DIRAS1	VGNC	VGNC:28069
Rattus norvegicus	DIRAS1	RGD	RGD:1310445
Canis familiaris	DIRAS1	VGNC	VGNC:39960
Mus musculus	DIRAS1	MGD	MGI:2183442

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