Haspin - histone H3 associated protein kinase Gene

Mus musculus

Also known as Gsg2

Gene ID: 14841 | Gene type: protein coding

About Haspin

Chromosome 11: 73,026,311-73,029,120 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 174 orthologues, 4 paralogues and is associated with 1 phenotype.

Summary

Enables ATP binding activity; DNA binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Haspin Products(1)

mRNA	Protein	Name
NM_010353.2	NP_034483.1	serine/threonine-protein kinase haspin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10358056	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	10358056	MGI
enables histone kinase activity	IMP IMP: Inferred from mutant phenotype	25645018	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10358056	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome organization involved in meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	25645018	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	25645018	MGI
involved in homologous chromosome segregation	IMP IMP: Inferred from mutant phenotype	25645018	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10358056	MGI
involved in meiotic cell cycle process	IMP IMP: Inferred from mutant phenotype	25645018	MGI
involved in meiotic metaphase I	IMP IMP: Inferred from mutant phenotype	25645018	MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	10358056	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10358056	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25645018	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	10358056	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10358056	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Haspin Protein Structure

PKc_like

0
200
400
600
754 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase haspin

germ cell associated 2, haspin	germ cell-specific gene 2 protein
haploid germ cell-specific nuclear protein kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect Inhibitor Pre-designed Sets	Purity	Rare Diseases Unkown
HY-15424	5-Iodotubercidin	Inhibitor	99.64%	Unkown
HY-15217	CHR-6494	Inhibitor	98.07%	Unkown
HY-13455	LDN-192960	Inhibitor	99.56%	Unkown
HY-146636	Haspin-IN-3	Inhibitor	98.14%	Unkown
HY-110320	LDN-209929 dihydrochloride	Inhibitor	98.43%	Unkown
HY-13455A	LDN-192960 hydrochloride	Inhibitor	99.78%	Unkown
HY-100368	MELK-8a	Inhibitor	98.32%	Unkown
HY-110350	CHR-6494 TFA	Inhibitor	/	Unkown
HY-146586	Haspin-IN-1	Inhibitor	/	Unkown
HY-146587	Haspin-IN-2	Inhibitor	/	Unkown
HY-155341	HSK205	Inhibitor	/	Unkown
HY-163858	Haspin-IN-4	Inhibitor	/	Unkown
HY-170546	MU1920	Inhibitor	/	Unkown
HY-RS06009	HASPIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06010	Haspin Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06011	Haspin Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-135002	LDN-209929	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Haspin	NCBI	NCBI:83903

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