CIART - circadian associated repressor of transcription Gene

Homo sapiens

Also known as GM129; CHRONO; C1orf51

Gene ID: 148523 | Gene type: protein coding

About CIART

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,282,554-150,287,093 (from NCBI)

This gene has 7 transcripts (splice variants) and 216 orthologues. Broad expression in heart (RPKM 6.9), thyroid (RPKM 5.6) and 24 other tissues.

Summary

Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Predicted to be located in PML body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CIART Products(5)

mRNA	Protein	Name
NM_001300838.2	NP_001287767.1	circadian-associated transcriptional repressor isoform a
NM_001300839.2	NP_001287768.1	circadian-associated transcriptional repressor isoform b
NM_001300840.2	NP_001287769.1	circadian-associated transcriptional repressor isoform b
NM_001300841.2	NP_001287770.1	circadian-associated transcriptional repressor isoform b
NM_144697.4	NP_653298.1	circadian-associated transcriptional repressor isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24385426	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

circadian-associated transcriptional repressor

chIP-derived repressor of network oscillator

CIART Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	CIART	Q8N365	Bmal1	Mus musculus	Q9WTL8	Anti Tag CoIP	24737000
Intra	CIART	Q8N365	DAB1	Homo sapiens	O75553	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gallbladder Benign Neoplasm

Gallbladder Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02705	CIART Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CIART	VGNC	VGNC:27358
Felis catus	CIART	VGNC	VGNC:60897
Macaca mulatta	CIART	VGNC	VGNC:71345
Rattus norvegicus	CIART	RGD	RGD:1566380
Mus musculus	CIART	MGD	MGI:2684975
Canis familiaris	CIART	VGNC	VGNC:39265

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