2. Gene
  3. Gucy2c - guanylate cyclase 2c Gene

Gucy2c - guanylate cyclase 2c Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gcc; GC-C

Gene ID: 14917 | Gene type: protein coding

About Gucy2c

Summary

Enables Guanylate Cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system and liver. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (Guanylate Cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]

Gucy2c Products(2)

mRNA Protein Name
NM_001127318.1 NP_001120790.1 guanylyl cyclase C isoform 1 precursor
NM_145067.3 NP_659504.2 guanylyl cyclase C isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables guanylate cyclase activity IMP
IMP: Inferred from mutant phenotype
9294128 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17681179 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
9294128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylyl cyclase C

STA receptor

heat-stable enterotoxin receptor

intestinal guanylate cyclase

Recombinant Gucy2c Proteins

Cat. No. Product Name Accession Purity
HY-P78742 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His) Q3UWA6-1 (V20-M433) ≥95%
HY-P700603 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, N-His, C-Myc) Q3UWA6-1 (V20-M433) ≥95%
HY-P700999 GUCY2C/Guanylyl cyclase C Protein, Mouse (Biotinylated, HEK293, His-Avi) Q3UWA6-1 (V20-M433) ≥95%
HY-P701000 GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His-Avi) Q3UWA6-1 (V20-M433) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05921 GUCY2C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99232 Indusatumab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gucy2c NCBI NCBI:2984
Canis familiaris Gucy2c NCBI NCBI:486671
Macaca fascicularis Gucy2c NCBI NCBI:102130850
Rattus norvegicus Gucy2c NCBI NCBI:25711