2. Gene
  3. Gzmb - granzyme B Gene

Gzmb - granzyme B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GZB; CCP1; Ctla1; Ctla-1; CCP-1/C11

Gene ID: 14939 | Gene type: protein coding

About Gzmb

Summary

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active Protease, which induces target cell Apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]

Gzmb Products(1)

mRNA Protein Name
NM_013542.3 NP_038570.1 granzyme B(G,H) preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15454490 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
35705808 MGI
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
16618603 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16618603 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
35705808 MGI
acts upstream of or within granzyme-mediated programmed cell death signaling pathway IDA
IDA: Inferred from direct assay
15454490 MGI
involved in granzyme-mediated programmed cell death signaling pathway IDA
IDA: Inferred from direct assay
35705808 MGI
acts upstream of or within granzyme-mediated programmed cell death signaling pathway IMP
IMP: Inferred from mutant phenotype
16618603 MGI
involved in protein maturation IDA
IDA: Inferred from direct assay
35705808 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytolytic granule IDA
IDA: Inferred from direct assay
19915045 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
35705808 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16618603 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
35482418 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

granzyme B(G,H)

cytotoxic cell protease 1

fragmentin-2

Recombinant Gzmb Proteins

Cat. No. Product Name Accession Purity
HY-P7185 Granzyme B/GZMB Protein, Mouse (CHO) P04187 (I21-S247) ≥95%
HY-P70253 Granzyme B/GZMB Protein, Mouse (HEK293, His, solution) P04187 (G19-S247) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149916 A2AR-antagonist-1 Antagonist / Unkown
HY-161982 JNU-0921 Agonist / Unkown
HY-RS05940 GZMB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gzmb NCBI NCBI:3002