SHLD1 - shieldin complex subunit 1 Gene

Homo sapiens

Also known as RINN3; C20orf196

Gene ID: 149840 | Gene type: protein coding

About SHLD1

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,750,193-5,864,395 (from NCBI)

This gene has 4 transcripts (splice variants) and 107 orthologues. Ubiquitous expression in lymph node (RPKM 1.6), adrenal (RPKM 1.1) and 24 other tissues.

Summary

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD1 Products(4)

mRNA	Protein	Name
NM_001303477.2	NP_001290406.1	shieldin complex subunit 1 isoform 1
NM_001303478.2	NP_001290407.1	shieldin complex subunit 1 isoform 2
NM_001303479.2	NP_001290408.1	shieldin complex subunit 1 isoform 3
NM_152504.4	NP_689717.2	shieldin complex subunit 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29656893	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	29656893	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	29656893	GOA
involved in positive regulation of isotype switching	IDA IDA: Inferred from direct assay	29656893	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	29656893	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	29656893	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHLD1 Protein Structure

DUF4521

0
100
205 a.a.

Protein Preferred Names

Protein Names

shieldin complex subunit 1

RINN1-REV7-interacting novel NHEJ regulator 3

SHLD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SHLD1	Q8IYI0	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SHLD1	Q8IYI0	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SHLD1	Q8IYI0	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SHLD1	Q8IYI0	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112210	Shield-1	Modulator	99.73%	Unkown
HY-RS12873	SHLD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SHLD1	VGNC	VGNC:49170
Canis familiaris	SHLD1	VGNC	VGNC:52529
Rattus norvegicus	SHLD1	RGD	RGD:1597982
Felis catus	SHLD1	VGNC	VGNC:65127
Mus musculus	SHLD1	MGD	MGI:1920997

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