DUSP18 - dual specificity phosphatase 18 Gene

Homo sapiens

Also known as DSP18; DUSP20; LMWDSP20

Gene ID: 150290 | Gene type: protein coding

About DUSP18

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,652,051-30,667,875 (from NCBI)

This gene has 10 transcripts (splice variants), 72 orthologues and 30 paralogues. Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP18 Products(4)

mRNA	Protein	Name
NM_001304794.2	NP_001291723.1	dual specificity protein phosphatase 18 isoform a
NM_001304795.2	NP_001291724.1	dual specificity protein phosphatase 18 isoform a
NM_001304796.2	NP_001291725.1	dual specificity protein phosphatase 18 isoform b
NM_152511.5	NP_689724.3	dual specificity protein phosphatase 18 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	24531476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28065597	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	12408986	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12591617	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	24531476	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	12591617	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	12408986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12408986	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12408986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP18 Protein Structure

DSPc

0
100
188 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 18

low molecular weight dual specificity phosphatase 20

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04058	DUSP18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DUSP18	MGD	MGI:1922469
Canis familiaris	DUSP18	VGNC	VGNC:52930
Bos taurus	DUSP18	VGNC	VGNC:50047
Rattus norvegicus	DUSP18	RGD	RGD:1306929
Macaca mulatta	DUSP18	VGNC	VGNC:71858

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