DUSP18 - dual specificity phosphatase 18 Gene

Homo sapiens

Also known as DSP18; DUSP20; LMWDSP20

Gene ID: 150290 | Gene type: protein coding

About DUSP18

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,652,051-30,667,875 (from NCBI)

This gene has 10 transcripts (splice variants), 72 orthologues and 30 paralogues. Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP18 Products(4)

mRNA	Protein	Name
NM_001304794.2	NP_001291723.1	dual specificity protein phosphatase 18 isoform a
NM_001304795.2	NP_001291724.1	dual specificity protein phosphatase 18 isoform a
NM_001304796.2	NP_001291725.1	dual specificity protein phosphatase 18 isoform b
NM_152511.5	NP_689724.3	dual specificity protein phosphatase 18 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	24531476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28065597	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	12408986	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12591617	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	24531476	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	12591617	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	12408986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12408986	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12408986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP18 Protein Structure

DSPc

0
100
188 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 18

low molecular weight dual specificity phosphatase 20

DUSP18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DUSP18	Q8NEJ0	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	DUSP18	Q8NEJ0	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	DUSP18	Q8NEJ0	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	DUSP18	Q8NEJ0	INSR	Homo sapiens	P06213	Ub Reconstruction	28065597

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04058	DUSP18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DUSP18	MGD	MGI:1922469
Canis familiaris	DUSP18	VGNC	VGNC:52930
Bos taurus	DUSP18	VGNC	VGNC:50047
Rattus norvegicus	DUSP18	RGD	RGD:1306929
Macaca mulatta	DUSP18	VGNC	VGNC:71858

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