PROM2 - prominin 2 Gene

Homo sapiens

Also known as PROML2

Gene ID: 150696 | Gene type: protein coding

About PROM2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,274,449-95,291,302 (from NCBI)

This gene has 11 transcripts (splice variants), 191 orthologues and 1 paralogue. Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues.

Summary

This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PROM2 Products(4)

mRNA	Protein	Name
NM_001165977.3	NP_001159449.1	prominin-2 isoform 1 precursor
NM_001165978.3	NP_001159450.1	prominin-2 isoform 1 precursor
NM_001321070.2	NP_001307999.1	prominin-2 isoform 2
NM_144707.4	NP_653308.2	prominin-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of caveolin-mediated endocytosis	IDA IDA: Inferred from direct assay	23583380	GOA
involved in negative regulation of pinocytosis	IDA IDA: Inferred from direct assay	23583380	GOA
involved in positive regulation of cell projection organization	IDA IDA: Inferred from direct assay	23583380	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	23583380	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	23583380	GOA
NOT involved in regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	23583380	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	23583380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROM2 Protein Structure

Prominin

0
200
400
600
834 a.a.

Protein Preferred Names

Protein Names

prominin-2

prominin-like protein 2

PROM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PROM2	Q8N271	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	PROM2	Q8N271	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	PROM2	Q8N271	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	PROM2	Q8N271	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	PROM2	Q8N271	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Maxillary Cancer

Maxillary Neoplasm	Maxillary Neoplasms
Upper Jaw Bone Cancer

Jaw Cancer

Jaw Neoplasms	Jaw Neoplasm
Neoplasm Of Jaw	Cancer Of Jaw

Retinal Degeneration

Degeneration Of Retina

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11199	PROM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PROM2	MGD	MGI:2138997
Macaca mulatta	PROM2	VGNC	VGNC:106200
Canis familiaris	PROM2	VGNC	VGNC:45013
Bos taurus	PROM2	VGNC	VGNC:33365
Felis catus	PROM2	VGNC	VGNC:64367
Rattus norvegicus	PROM2	RGD	RGD:621435

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