CTSE - cathepsin E Gene

Homo sapiens

Also known as CATE

Gene ID: 1510 | Gene type: protein coding

About CTSE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,009,264-206,023,895 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues and 9 paralogues. Biased expression in stomach (RPKM 543.0) and duodenum (RPKM 112.5).

Summary

This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature Enzyme. This Enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

CTSE Products(5)

mRNA	Protein	Name
XM_011509245.2	XP_011507547.1	cathepsin E isoform X2
XM_011509244.2	XP_011507546.1	cathepsin E isoform X1
NM_148964.3	NP_683865.1	cathepsin E isoform b precursor
NM_001317331.2	NP_001304260.1	cathepsin E isoform c
NM_001910.4	NP_001901.1	cathepsin E isoform a preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	7789521	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	16997486	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	8765029	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	16997486	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	7983070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSE Protein Structure

A1_Propeptide

Asp

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

cathepsin E

erythrocyte membrane aspartic proteinase

slow-moving proteinase

Recombinant CTSE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7750	Cathepsin E Protein, Human (HEK293, His)	P14091 (S20-P396)	≥95%

Related Diseases

Diseases

Alias

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Gastric Cancer

Stomach Cancer	Stomach Carcinoma
Gastric Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Ceroid Lipofuscinosis, Neuronal, 10

Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency	Neuronal Ceroid Lipofuscinosis 10
CLN10	Cathepsin D Deficiency
Congenital Neuronal Ceroid Lipofuscinosis	Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient
Cln10 Disease	Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient
Cln10 Disease, Adult	Cln10 Disease, Congenital
Cln10 Disease, Juvenile	Cln10 Disease, Late Infantile
Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient	Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis
Congenital Ncl	Lipofuscinosis, Ceroid, Neuronal, Type 10
Neuronal Ceroid Lipofuscinosis, Congenital

Gastric Papillary Adenocarcinoma

Papillary Adenocarcinoma Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03331	CTSE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03332	Ctse Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03333	Ctse Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTSE	VGNC	VGNC:71554
Canis familiaris	CTSE	VGNC	VGNC:39710
Mus musculus	CTSE	MGD	MGI:107361
Rattus norvegicus	CTSE	RGD	RGD:2446
Felis catus	CTSE	VGNC	VGNC:61267
Others	CTSE	NCBI

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