CTSG - cathepsin G Gene

Homo sapiens

Also known as CG; CATG

Gene ID: 1511 | Gene type: protein coding

About CTSG

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,573,518-24,576,250 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 6 paralogues. Restricted expression toward bone marrow (RPKM 1559.4).

Summary

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

CTSG Products(1)

mRNA	Protein	Name
NM_001911.3	NP_001902.1	cathepsin G preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables caspase binding	IPI IPI: Inferred from physical interaction	29077095	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	11907569	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	11907569	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	15210802	GOA
enables serine-type endopeptidase activity	EXP EXP: Inferred from Experiment	10512690	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	8194606	GOA
enables serine-type peptidase activity	IMP IMP: Inferred from mutant phenotype	1937776	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	1937776	GOA
involved in biofilm matrix disassembly	IDA IDA: Inferred from direct assay	32995850	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	1937776	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	1937776	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	2116408	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	15210802	GOA
involved in negative regulation of T cell activation	IDA IDA: Inferred from direct assay	15100291	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	22879591	GOA
involved in platelet activation	IDA IDA: Inferred from direct assay	10702240	GOA
involved in positive regulation of platelet aggregation	IDA IDA: Inferred from direct assay	3390156	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8573071	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	7744748	GOA
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	11907569	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	1861080	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	1937776	GOA
located in cytosol	IDA IDA: Inferred from direct assay	29077095	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3390156	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15100291	GOA
located in membrane	IDA IDA: Inferred from direct assay	29077095	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11259672	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	1861080	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	11907569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSG Protein Structure

Trypsin

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

cathepsin G

CTSG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTSG	P08311	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CTSG	P08311	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CTSG	P08311	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CTSG	P08311	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CTSG	P08311	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	CTSG	P08311	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	CTSG	P08311	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	CTSG	P08311	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	CTSG	P08311	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	CTSG	P08311	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Gingivitis

Chronic Gingivitis

Acute Gingivitis

Bronchiectasis

Polynesian Bronchiectasis	Kartagener Syndrome
Bronchiectasis Nos

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease	Papillon-Lefèvre Syndrome
PLS	Keratosis Palmoplantaris With Periodontopathia
PALS	Papillon Lefevre Syndrome
Keratosis Palmoplantar-Periodontopathy Syndrome	Papillon-Lefvre Syndrome
Hyperkeratosis Palmoplantaris With Periodontosis	Keratoris Palmoplantaris With Periodontopathia
Keratosis Palmoplantar - Periodontopathy	Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction
Palmoplantar Keratoderma With Periodontosis	Palsy

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Glomerulonephritis

Bright'S Disease

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Mast Cell Neoplasm

Mastocytoma	Mast Cell Proliferative Disease
Mast Cell Tumor	Benign Mastocytoma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Plasma Protein Metabolism Disease

Granulomatous Endometritis

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03335	CTSG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CTSG	VGNC	VGNC:39712
Mus musculus	CTSG	MGD	MGI:88563
Rattus norvegicus	CTSG	RGD	RGD:1307681
Macaca mulatta	CTSG	VGNC	VGNC:71556

Name
Email *

	Sorry, but the email address you supplied was invalid.