METTL21A - methyltransferase 21A, HSPA lysine Gene

Homo sapiens

Also known as FAM119A; HCA557b; HSPA-KMT

Gene ID: 151194 | Gene type: protein coding

About METTL21A

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,580,635-207,626,053 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues.

Summary

Enables ATPase binding activity; HSP70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL21A Products(26)

mRNA	Protein	Name
NM_001127395.5	NP_001120867.1	protein N-lysine methyltransferase METTL21A isoform 1
NM_001308021.3	NP_001294950.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001330130.2	NP_001317059.1	protein N-lysine methyltransferase METTL21A isoform 1
NM_001330131.2	NP_001317060.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_001330132.3	NP_001317061.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001330133.3	NP_001317062.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_001330134.2	NP_001317063.1	protein N-lysine methyltransferase METTL21A isoform 1
NM_001330135.2	NP_001317064.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_001330136.3	NP_001317065.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001330137.2	NP_001317066.1	protein N-lysine methyltransferase METTL21A isoform 4
NM_001388427.1	NP_001375356.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001388439.2	NP_001375368.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001393563.1	NP_001380492.1	protein N-lysine methyltransferase METTL21A isoform 5
NM_001393564.1	NP_001380493.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001393565.1	NP_001380494.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001393566.1	NP_001380495.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001393567.1	NP_001380496.1	protein N-lysine methyltransferase METTL21A isoform 2
NM_001393568.1	NP_001380497.1	protein N-lysine methyltransferase METTL21A isoform 6
NM_001393569.1	NP_001380498.1	protein N-lysine methyltransferase METTL21A isoform 7
NM_001393570.1	NP_001380499.1	protein N-lysine methyltransferase METTL21A isoform 7
NM_001393571.1	NP_001380500.1	protein N-lysine methyltransferase METTL21A isoform 8
NM_001393572.1	NP_001380501.1	protein N-lysine methyltransferase METTL21A isoform 8
NM_001393573.1	NP_001380502.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_001393574.1	NP_001380503.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_001393575.1	NP_001380504.1	protein N-lysine methyltransferase METTL21A isoform 3
NM_145280.7	NP_660323.3	protein N-lysine methyltransferase METTL21A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	23349634	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	23349634	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	22948820	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-lysine methylation	IDA IDA: Inferred from direct assay	23921388	GOA
involved in protein methylation	IDA IDA: Inferred from direct assay	22948820	GOA
NOT involved in regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	23921388	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL21A Protein Structure

Methyltransf_16

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

protein N-lysine methyltransferase METTL21A

HSPA lysine methyltransferase

METTL21A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL21A	Q8WXB1	MSRB3	Homo sapiens	Q8IXL7-2	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	MSRB3	Homo sapiens	Q8IXL7-2	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	METTL21A	Q8WXB1	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	ARPC4	Homo sapiens	P59998	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	ARPC4	Homo sapiens	P59998	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	METTL21A	Q8WXB1	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	METTL21A	Q8WXB1	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	FAM200C	Homo sapiens	Q8IZ13	Y2H	21516116
Intra	METTL21A	Q8WXB1	FAM200C	Homo sapiens	Q8IZ13	Y2H Array	31515488
Intra	METTL21A	Q8WXB1	FAM200C	Homo sapiens	Q8IZ13	Y2H Prey Pooling	32296183
Intra	METTL21A	Q8WXB1	FAM200C	Homo sapiens	Q8IZ13	Y2H Array	32296183
Intra	METTL21A	Q8WXB1	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	METTL21A	Q8WXB1	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	METTL21A	Q8WXB1	ATRIP	Homo sapiens	Q8WXE1	Y2H Array	25416956
Intra	METTL21A	Q8WXB1	ATRIP	Homo sapiens	Q8WXE1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 2a

Pontocerebellar Hypoplasia Type 2a	PCH2A
Pch2	Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy
Volendam Neurodegenerative Disease	Pontocerebellar Hypoplasia 2a
Hypoplasia, Pontocerebellar, Type 2a

Malignant Ovarian Cyst

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08360	METTL21A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	METTL21A	VGNC	VGNC:74625
Mus musculus	METTL21A	MGD	MGI:1914349
Rattus norvegicus	METTL21A	RGD	RGD:7651604
Bos taurus	METTL21A	VGNC	VGNC:31406
Felis catus	METTL21A	VGNC	VGNC:80279
Canis familiaris	METTL21A	VGNC	VGNC:57396

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