MEI4 - meiotic double-stranded break formation protein 4 Gene

Homo sapiens

Gene ID: 101928601 | Gene type: protein coding

About MEI4

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:77,650,274-77,927,045 (from NCBI)

This gene has 3 transcripts (splice variants) and 168 orthologues. Biased expression in kidney (RPKM 2.5), testis (RPKM 1.9) and 6 other tissues.

Summary

Predicted to be involved in gamete generation and meiosis I cell cycle process. Predicted to be active in lateral element. [provided by Alliance of Genome Resources, Apr 2022]

MEI4 Products(2)

mRNA	Protein	Name
NM_001282136.3	NP_001269065.1	meiosis-specific protein MEI4
NM_001322247.2	NP_001309176.1	meiosis-specific protein MEI4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31704776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEI4 Protein Structure

Mei4

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

meiosis-specific protein MEI4

meiosis-specific 4 homolog

MEI4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MEI4	A8MW99	CHAF1A	Homo sapiens	Q13111	Validated Y2H	32296183
Intra	MEI4	A8MW99	TRIM59	Homo sapiens	Q8IWR1	Validated Y2H	32296183
Intra	MEI4	A8MW99	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	MEI4	A8MW99	CABP5	Homo sapiens	Q9NP86	Validated Y2H	32296183
Intra	MEI4	A8MW99	NGB	Homo sapiens	Q9NPG2	Validated Y2H	32296183
Intra	MEI4	A8MW99	POLR1C	Homo sapiens	O15160	Validated Y2H	32296183
Intra	MEI4	A8MW99	TRAPPC2L	Homo sapiens	Q9UL33-2	Validated Y2H	32296183
Intra	MEI4	A8MW99	DNTT	Homo sapiens	P04053	Validated Y2H	32296183
Intra	MEI4	A8MW99	DNTT	Homo sapiens	P04053	Y2H Array	32296183
Intra	MEI4	A8MW99	PLEKHA4	Homo sapiens	Q9H4M7-2	Validated Y2H	32296183
Intra	MEI4	A8MW99	AFMID	Homo sapiens	Q63HM1	Validated Y2H	32296183
Intra	MEI4	A8MW99	MYO5B	Homo sapiens	Q9ULV0-2	Validated Y2H	32296183
Intra	MEI4	A8MW99	CTTNBP2	Homo sapiens	Q8WZ74	Validated Y2H	32296183
Intra	MEI4	A8MW99	REC114	Homo sapiens	Q7Z4M0	Anti Tag CoIP	38148155
Intra	MEI4	A8MW99	MACO1	Homo sapiens	Q8N5G2	Validated Y2H	32296183
Intra	MEI4	A8MW99	BAG4	Homo sapiens	O95429	Validated Y2H	32296183
Intra	MEI4	A8MW99	IQGAP1	Homo sapiens	P46940	Validated Y2H	32296183
Intra	MEI4	A8MW99	TSEN15	Homo sapiens	Q8WW01	Validated Y2H	32296183
Intra	MEI4	A8MW99	EIF5A	Homo sapiens	P63241	Validated Y2H	32296183
Intra	MEI4	A8MW99	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	MEI4	A8MW99	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	MEI4	A8MW99	CST9L	Homo sapiens	Q9H4G1	Validated Y2H	32296183
Intra	MEI4	A8MW99	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
Intra	MEI4	A8MW99	CPNE2	Homo sapiens	Q96FN4	Validated Y2H	32296183
Intra	MEI4	A8MW99	PAFAH1B3	Homo sapiens	Q15102	Validated Y2H	32296183
Intra	MEI4	A8MW99	VPS26C	Homo sapiens	O14972	Validated Y2H	32296183
Intra	MEI4	A8MW99	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	MEI4	A8MW99	C19orf25	Homo sapiens	Q9UFG5	Validated Y2H	32296183
Intra	MEI4	A8MW99	MTMR9	Homo sapiens	Q96QG7	Validated Y2H	32296183
Intra	MEI4	A8MW99	FKBP6	Homo sapiens	O75344	Validated Y2H	32296183
Intra	MEI4	A8MW99	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	MEI4	A8MW99	CDKN2D	Homo sapiens	P55273	Validated Y2H	32296183
Intra	MEI4	A8MW99	PHYHIPL	Homo sapiens	Q96FC7	Validated Y2H	32296183
Intra	MEI4	A8MW99	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	MEI4	A8MW99	METTL21A	Homo sapiens	Q8WXB1	Validated Y2H	32296183
Intra	MEI4	A8MW99	MLX	Homo sapiens	Q9UH92-3	Validated Y2H	32296183
Intra	MEI4	A8MW99	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	32296183
Intra	MEI4	A8MW99	R3HDM2	Homo sapiens	Q9Y2K5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08320	MEI4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MEI4	VGNC	VGNC:43150
Felis catus	MEI4	VGNC	VGNC:102460
Bos taurus	MEI4	VGNC	VGNC:106818
Macaca mulatta	MEI4	VGNC	VGNC:74638
Rattus norvegicus	MEI4	RGD	RGD:1583682
Mus musculus	MEI4	MGD	MGI:1922283

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