CTSH - cathepsin H Gene

Homo sapiens

Also known as ACC4; ACC5; CPSB; ACC-4; ACC-5

Gene ID: 1512 | Gene type: protein coding

About CTSH

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,921,058-78,945,046 (from NCBI)

This gene has 69 transcripts (splice variants), 225 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 144.1), kidney (RPKM 97.7) and 24 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an Aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTSH Products(3)

mRNA	Protein	Name
NM_001319137.2	NP_001306066.1	pro-cathepsin H isoform c
NM_001411095.1	NP_001398024.1	pro-cathepsin H isoform d
NM_004390.5	NP_004381.2	pro-cathepsin H isoform a preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables HLA-A specific activating MHC class I receptor activity	IDA IDA: Inferred from direct assay	16822283	GOA
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	15127951	GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	20435891	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	6203523	GOA
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	8811434	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	14766755	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	18216060	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	6203523	GOA
enables thyroid hormone binding	IDA IDA: Inferred from direct assay	21217776	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21217776	GOA
involved in adaptive immune response	IEP IEP: Inferred from expression pattern	15196205	GOA
involved in bradykinin catabolic process	IDA IDA: Inferred from direct assay	15127951	GOA
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	21217776	GOA
involved in immune response-regulating signaling pathway	IDA IDA: Inferred from direct assay	16822283	GOA
involved in membrane protein proteolysis	IDA IDA: Inferred from direct assay	14766755	GOA
involved in neuropeptide catabolic process	IDA IDA: Inferred from direct assay	15127951	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	21217776	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21217776	GOA
involved in positive regulation of peptidase activity	IDA IDA: Inferred from direct assay	20435891	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	17500053	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	6203523	GOA
involved in surfactant homeostasis	IDA IDA: Inferred from direct assay	18216060	GOA
involved in zymogen activation	IDA IDA: Inferred from direct assay	20435891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in alveolar lamellar body	IDA IDA: Inferred from direct assay	18216060	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9050938	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	9050938	GOA
located in lysosome	IDA IDA: Inferred from direct assay	1837142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSH Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

pro-cathepsin H

N-benzoylarginine-beta-naphthylamide hydrolase

CTSH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTSH	P09668	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	CTSH	P09668	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	CTSH	P09668	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	CTSH	P09668	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	CTSH	P09668	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	CTSH	P09668	KLK6	Homo sapiens	Q92876	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Narcolepsy 1

NRCLP1	Narcoleptic Syndrome 1
Gelineau Disease	Narcolepsy-Cataplexy
Narcolepsy-Cataplexy Syndrome	Narcolepsy, Type 1
Narcolepsy Type 1	Cataplexy
Gélineau'S Syndrome	Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70227	Cathepsin G, human neutrophils		90.00%	Unkown
HY-RS03336	CTSH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CTSH	RGD	RGD:2447
Bos taurus	CTSH	VGNC	VGNC:27816
Canis familiaris	CTSH	VGNC	VGNC:39713
Macaca mulatta	CTSH	VGNC	VGNC:71558
Felis catus	CTSH	VGNC	VGNC:61268
Mus musculus	CTSH	MGD	MGI:107285
Others	CTSH	NCBI

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