PPP1R1C - protein phosphatase 1 regulatory inhibitor subunit 1C Gene

Homo sapiens

Also known as IPP5

Gene ID: 151242 | Gene type: protein coding

About PPP1R1C

Cytogenetic location: 2q31.3-q32.1 Genomic coordinates (GRCh38): 2:181,954,480-182,131,385 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in heart (RPKM 4.6), testis (RPKM 4.4) and 5 other tissues.

Summary

Protein phosphatase-1 (PP1) is a major serine/threonine Phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

PPP1R1C Products(3)

mRNA	Protein	Name
NM_001080545.3	NP_001074014.1	protein phosphatase 1 regulatory subunit 1C isoform 2
NM_001261424.2	NP_001248353.1	protein phosphatase 1 regulatory subunit 1C isoform 1
NM_001261425.2	NP_001248354.1	protein phosphatase 1 regulatory subunit 1C isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R1C Protein Structure

DARPP-32

0
100
109 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 1C

PP1 inhibitor protein 5

PPP1R1C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R1C	Q8WVI7	TNPO3	Homo sapiens	Q9Y5L0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Conduct Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10994	PPP1R1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP1R1C	VGNC	VGNC:33235
Canis familiaris	PPP1R1C	VGNC	VGNC:44888
Felis catus	PPP1R1C	VGNC	VGNC:80317
Macaca mulatta	PPP1R1C	VGNC	VGNC:76256
Mus musculus	PPP1R1C	MGD	MGI:1923185
Rattus norvegicus	PPP1R1C	RGD	RGD:1562095

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