2. Gene
  3. TNPO3 - transportin 3 Gene

TNPO3 - transportin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IPO12; TRNSR; LGMD1F; LGMDD2; MTR10A; TRN-SR; TRN-SR2

Gene ID: 23534 | Gene type: protein coding

About TNPO3

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,954,185-129,056,193 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 16.7), thyroid (RPKM 13.7) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 Infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]

TNPO3 Products(10)

mRNA Protein Name
NM_001191028.3 NP_001177957.2 transportin-3 isoform 2
NM_001382216.1 NP_001369145.1 transportin-3 isoform 3
NM_001382217.1 NP_001369146.1 transportin-3 isoform 4
NM_001382218.1 NP_001369147.1 transportin-3 isoform 5
NM_001382219.1 NP_001369148.1 transportin-3 isoform 6
NM_001382220.1 NP_001369149.1 transportin-3 isoform 7
NM_001382221.1 NP_001369150.1 transportin-3 isoform 8
NM_001382222.1 NP_001369151.1 transportin-3 isoform 9
NM_001382223.1 NP_001369152.1 transportin-3 isoform 10
NM_012470.4 NP_036602.1 transportin-3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22872640 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12628928 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
23878195 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
12628928 GOA
Cellular Component GO Annotation Evidence Reference Source
located in annulate lamellae IDA
IDA: Inferred from direct assay
31192305 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
31192305 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNPO3 Protein Structure

Xpo1

Xpo1: Exportin 1-like protein (102 - 248)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 923 a.a.
Protein Preferred Names Protein Names

transportin-3

imp12

TNPO3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TNPO3 Q9Y5L0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 TNPO3 Homo sapiens Q9Y5L0
Solution Sedimentation
22872640
Intra
TNPO3 Q9Y5L0 TNPO3 Homo sapiens Q9Y5L0
GMS
22872640
Intra
TNPO3 Q9Y5L0 CLK3 Homo sapiens P49761
Anti Tag CoIP
35271311
Intra
TNPO3 Q9Y5L0 TNPO3 Homo sapiens Q9Y5L0
SAXS
22872640
Intra
TNPO3 Q9Y5L0 CLPP Homo sapiens Q16740
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 CLPP Homo sapiens Q16740
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 CAMK2B Homo sapiens Q13554-3
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 CAMK2B Homo sapiens Q13554-3
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 CAMK2D Homo sapiens Q13557-8
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 CAMK2D Homo sapiens Q13557-8
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 CAMK2G Homo sapiens Q13555-5
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 CAMK2G Homo sapiens Q13555-5
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 ICA1L Homo sapiens Q8NDH6-2
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 ICA1L Homo sapiens Q8NDH6-2
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 SSX2 Homo sapiens Q16385-2
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 SSX2 Homo sapiens Q16385-2
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 PPP1R1C Homo sapiens Q8WVI7
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 PPP1R1C Homo sapiens Q8WVI7
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 ECI2 Homo sapiens O75521
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 ECI2 Homo sapiens O75521
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 BLMH Homo sapiens Q13867
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 BLMH Homo sapiens Q13867
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 NME1 Homo sapiens P15531
Y2H Array
32296183
Intra
TNPO3 Q9Y5L0 NME1 Homo sapiens P15531
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 GCH1 Homo sapiens P30793
Y2H Prey Pooling
32296183
Intra
TNPO3 Q9Y5L0 GCH1 Homo sapiens P30793
Y2H Array
32296183
Cross
TNPO3 Q9Y5L0 P04585-PRO_0000042447 Human immunodeficiency virus P04585-PRO_0000042447
GMS
22872640
Cross
TNPO3 Q9Y5L0 P04585-PRO_0000042447 Human immunodeficiency virus P04585-PRO_0000042447
Pull Down
22872640
Cross: Cross-species interaction Intra: Intraspecies interaction

TNPO3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82241 TNPO3 Antibody (YA1986) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2

Muscular Dystrophy, Limb-Girdle, Type 1f

Lgmd1f

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1f

LGMDD2

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 2

Muscular Dystrophy Limb-Girdle Type 1f

Tnp03-Related Limb-Girdle Muscular Dystrophy D2

Lgmd Type 1f

Limb-Girdle Muscular Dystrophy Type 1f

Limb-Girdle Muscular Dystrophy 1f

Dystrophy, Muscular, Limb-Girdle, Type 1f
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
Autosomal Dominant Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Dominant
Muscular Dystrophy, Limb-Girdle, Type 1h

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1h

LGMD1H

Muscular Dystrophy Limb-Girdle Type 1h

Dystrophy, Muscular, Limb-Girdle, Type 1h
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 3

Lgmd1g

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1g

LGMDD3

Muscular Dystrophy, Limb-Girdle, Type 1g

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 3

Limb-Girdle Muscular Dystrophy, Type 1g

Muscular Dystrophy Limb-Girdle Type 1g

Hnrnpdl-Related Limb-Girdle Muscular Dystrophy D3

Hnrnpdl-Related Lgmd D3

Lgmd Type 1g

Limb-Girdle Muscular Dystrophy Type 1g

Limb-Girdle Muscular Dystrophy 1g

Dystrophy, Muscular, Limb-Girdle, Type 1g
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2

Lgmd2b

Muscular Dystrophy, Limb-Girdle, Type 2b

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e

Beta-Sarcoglycanopathy

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2y

Muscular Dystrophy, Limb-Girdle, Type 3

Lgmd3

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2s

LGMDR2

Muscular Dystrophy, Limb-Girdle, Type 2s

Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2e

Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency

Muscular Dystrophy, Limb-Girdle, Type 2e

Lgmd2s

Autosomal Recessive Muscular Dystrophy Due To Lap1b Deficiency

Autosomal Recessive Muscular Dystrophy Due To Torsin-1a-Interacting Protein 1 Deficiency

Lgmd2y

Muscular Dystrophy With Progressive Weakness, Distal Contractures And Rigid Spine

Muscular Dystrophy, Limb-Girdle, Type 2y

Dysferlin-Related Limb-Girdle Muscular Dystrophy R2

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Dysferlin-Related Lgmd R2

Lgmd Due To Dysferlin Deficiency

Lgmd Type 2b

Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

Limb-Girdle Muscular Dystrophy 2b

Limb-Girdle Muscular Dystrophy, Type 2b

Dystrophy, Muscular, Limb-Girdle, Autosomal Recessive, Type 2

Dystrophy, Muscular, Limb-Girdle, Type 2b

Limb-Girdle Muscular Dystrophy, Type 2e
Myopathy, Myofibrillar, 6

Myofibrillar Myopathy 6

MFM6

Myopathy, Myofibrillar, Bag3-Related

Bag3-Related Myofibrillar Myopathy

Muscular Dystrophy, Selcen Type

Mfm Bag3-Related

Muscular Dystrophy Selcen Type

Myopathy Myofibrillar Bag3-Related
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2w

Lgmd2w

Muscular Dystrophy, Limb-Girdle, Type 2w
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1

Muscular Dystrophy, Limb-Girdle, Type 1e

Lgmd1d

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d

LGMDD1

Lgmd1e

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1

Limb-Girdle Muscular Dystrophy Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly

Lgmd1d, Formerly

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e

Muscular Dystrophy Limb-Girdle Type 1d

Muscular Dystrophy Limb-Girdle Type 1e

Dnajb6-Related Limb-Girdle Muscular Dystrophy D1

Dnajb6-Related Lgmd D1

Lgmd Type 1d

Limb-Girdle Muscular Dystrophy 1e

Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant

Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1

Dystrophy, Muscular, Limb-Girdle, Type 1e
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2q

Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Plectin Deficiency

Lgmd2q

Muscular Dystrophy, Limb-Girdle, Type 2q
Muscular Dystrophy-Dystroglycanopathy , Type C, 7

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2u

Lgmd2u

MDDGC7

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 20

Lgmdr20

Muscular Dystrophy, Limb-Girdle, Type 2u

Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Ispd Deficiency

Muscular Dystrophy Limb-Girdle Type 2u

Muscular Dystrophy-Dystroglycanopathy Type C7

Ispd-Related Limb-Girdle Muscular Dystrophy R20

Ispd-Related Lgmd R20

Lgmd Type 2u

Limb-Girdle Muscular Dystrophy Type 2u

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C7

Dystrophy, Muscular, Dystroglycanopathy, Type C7
Myopathy

Muscular Diseases

Myopathies
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14861 TNPO3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TNPO3 VGNC VGNC:66432
Macaca mulatta TNPO3 VGNC VGNC:79063
Canis familiaris TNPO3 VGNC VGNC:47696
Rattus norvegicus TNPO3 RGD RGD:1308938
Mus musculus TNPO3 MGD MGI:1196412
Bos taurus TNPO3 VGNC VGNC:36201