2. Gene
  3. ADRA2C - adrenoceptor alpha 2C Gene

ADRA2C - adrenoceptor alpha 2C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR

Gene ID: 152 | Gene type: protein coding

About ADRA2C

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,766,385-3,768,526 (from NCBI)

This gene has 2 transcripts (splice variants), 228 orthologues, 18 paralogues and is associated with 1 phenotype.

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

ADRA2C Products(1)

mRNA Protein Name
NM_000683.4 NP_000674.2 alpha-2C adrenergic receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha-2A adrenergic receptor binding IPI
IPI: Inferred from physical interaction
16605244 GOA
enables alpha2-adrenergic receptor activity EXP
EXP: Inferred from Experiment
10948191 GOA
enables alpha2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
17215105 GOA
enables epinephrine binding IDA
IDA: Inferred from direct assay
17215105 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16531006 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16605244 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16605244 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in activation of protein kinase B activity IDA
IDA: Inferred from direct assay
17215105 GOA
involved in adrenergic receptor signaling pathway IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
17215105 GOA
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17215105 GOA
involved in receptor transactivation IDA
IDA: Inferred from direct assay
17215105 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16605244 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16605244 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA2C Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

alpha-2C adrenergic receptor

adrenergic, alpha-2C-, receptor

ADRA2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ADRA2C P18825 P4HA3 Homo sapiens Q7Z4N8
Validated Y2H
32296183
Intra
ADRA2C P18825 CNPY2 Homo sapiens Q9Y2B0
Validated Y2H
32296183
Intra
ADRA2C P18825 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
ADRA2C P18825 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
ADRA2C P18825 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
Intra
ADRA2C P18825 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
ADRA2C P18825 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ADRA2C P18825 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Raynaud Disease

Raynaud'S Disease

Raynaud Phenomenon

Raynaud'S Syndrome

Raynaud'S

Cold Fingers, Hereditary

Raynaud'S Phenomenon

Raynaud'S Disease/Phenomenon

Raynauds Syndrome

Raynauds Phenomenon

Secondary Raynaud'S Phenomenon

Raynaud Syndrome
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Type 1 Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, 22

IDDM22

T1D22

Insulin-Dependent Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, Type 22
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Horner'S Syndrome

Horner Syndrome

Bernard-Horner Syndrome

Oculosympathetic Palsy

Bernard Horner Syndrome

Cervical Sympathetic Paralysis

Von Passow Syndrome

Cervical Sympathetic Dystrophy
Long Qt Syndrome 1

Romano-Ward Syndrome

LQT1

Ward-Romano Syndrome

Rws

Ventricular Fibrillation With Prolonged Qt Interval

Wrs

Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00413 ADRA2C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADRA2C MGD MGI:87936
Macaca mulatta ADRA2C VGNC VGNC:69727
Rattus norvegicus ADRA2C RGD RGD:2058
Felis catus ADRA2C VGNC VGNC:59657
Bos taurus ADRA2C VGNC VGNC:106633