SPICE1 - spindle and centriole associated protein 1 Gene

Homo sapiens

Also known as SPICE; CCDC52

Gene ID: 152185 | Gene type: protein coding

About SPICE1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:113,442,718-113,515,156 (from NCBI)

This gene has 7 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues.

Summary

Involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

SPICE1 Products(4)

mRNA	Protein	Name
NM_001331078.2	NP_001318007.1	spindle and centriole-associated protein 1
NM_001331079.2	NP_001318008.2	spindle and centriole-associated protein 1
NM_001387939.1	NP_001374868.1	spindle and centriole-associated protein 1
NM_144718.4	NP_653319.1	spindle and centriole-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20736305	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20736305	GOA
involved in regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	20736305	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	20736305	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in spindle	IDA IDA: Inferred from direct assay	20736305	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spindle and centriole-associated protein 1

coiled-coil domain-containing protein 52

Related Diseases

Diseases

Alias

Arthrogryposis Multiplex Congenita-3

Ciliary Dyskinesia, Primary, 43

CILD43	Primary Ciliary Dyskinesia 43
Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus
Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome	Bcd Syndrome
Elschnig Syndrome	Clefting, Ectropion, And Conical Teeth
Lagophthalmia With Bilateral Cleft Lip And Palate	Blepharo-Cheilo-Odontic Syndrome
Bcds	Ectropion, Inferior, With Cleft Lip And/Or Palate
Blepharo-Cheilo-Dontic Syndrome	BCDS1
Ectropion Inferior Cleft Lip And Or Palate	Clefting-Ectropion-Conical Teeth Syndrome
Ectropion Inferior-Cleft Lip And/Or Palate Syndrome	Lagophthalmia-Cleft Lip And Palate Syndrome
Blepharocheilodontic Syndrome, Type 1

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13673	SPICE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPICE1	RGD	RGD:1310729
Canis familiaris	SPICE1	VGNC	VGNC:46740
Mus musculus	SPICE1	MGD	MGI:1196252
Bos taurus	SPICE1	VGNC	VGNC:35215
Felis catus	SPICE1	VGNC	VGNC:102848
Macaca mulatta	SPICE1	VGNC	VGNC:82732

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