CREBRF - CREB3 regulatory factor Gene

Homo sapiens

Also known as LRF; C5orf41

Gene ID: 153222 | Gene type: protein coding

About CREBRF

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:173,056,352-173,139,284 (from NCBI)

This gene has 6 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 12.2), bone marrow (RPKM 8.3) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of transport; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

CREBRF Products(3)

mRNA	Protein	Name
NM_001168393.2	NP_001161865.1	CREB3 regulatory factor isoform 2
NM_001168394.2	NP_001161866.1	CREB3 regulatory factor isoform 2
NM_153607.3	NP_705835.2	CREB3 regulatory factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16940180	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16940180	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18391022	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	18391022	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18391022	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	18391022	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16940180	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	18391022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18391022	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	18391022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CREB3 regulatory factor

UPF0474 protein C5orf41

CREBRF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CREBRF	Q8IUR6	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	CREBRF	Q8IUR6	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	CREBRF	Q8IUR6	CREB3	Homo sapiens	O43889-2	Pull Down	18391022

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Enophthalmos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03159	CREBRF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CREBRF	VGNC	VGNC:61173
Bos taurus	CREBRF	VGNC	VGNC:27700
Macaca mulatta	CREBRF	VGNC	VGNC:71506
Canis familiaris	CREBRF	VGNC	VGNC:39603
Rattus norvegicus	CREBRF	RGD	RGD:1310862
Mus musculus	CREBRF	MGD	MGI:1924378

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