MBLAC2 - metallo-beta-lactamase domain containing 2 Gene

Homo sapiens

Gene ID: 153364 | Gene type: protein coding

About MBLAC2

This gene has 2 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.5), ovary (RPKM 4.5) and 25 other tissues.

Summary

Enables palmitoyl-CoA hydrolase activity. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MBLAC2 Products(1)

mRNA	Protein	Name
NM_203406.2	NP_981951.2	acyl-coenzyme A thioesterase MBLAC2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-lactamase activity	IDA IDA: Inferred from direct assay	31434986	GOA
enables long-chain fatty acyl-CoA hydrolase activity	IMP IMP: Inferred from mutant phenotype	33219126	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	33219126	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	33219126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MBLAC2 Protein Structure

Lactamase_B

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A thioesterase MBLAC2

acyl-CoA thioesterase MBLAC2

MBLAC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MBLAC2	Q68D91	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Jalili Syndrome

Cone-Rod Dystrophy And Amelogenesis Imperfecta	Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome
Cone-Rod Dystrophy Amelogenesis Imperfecta	Cone-Rod Dystrophy With Amelogenesis Imperfecta
JALIS	Cone Rod Dystrophy Amelogenesis Imperfecta

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13322	Pracinostat		99.82%	Yes
HY-105246	Pracinostat dihydrochloride		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13271A	Tubastatin A		98.37%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-13271	Tubastatin A Hydrochloride		98.19%	Unkown
HY-19328	ACY-775	Inhibitor	99.69%	Unkown
HY-100871	WT-161		98.36%	Unkown
HY-13271B	Tubastatin A TFA		/	Unkown
HY-RS08189	MBLAC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MBLAC2	VGNC	VGNC:110452
Mus musculus	MBLAC2	MGD	MGI:1920102
Bos taurus	MBLAC2	VGNC	VGNC:31282
Felis catus	MBLAC2	VGNC	VGNC:63400
Canis familiaris	MBLAC2	VGNC	VGNC:43056
Rattus norvegicus	MBLAC2	RGD	RGD:1306703

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