IRX2 - iroquois homeobox 2 Gene

Homo sapiens

Also known as IRXA2

Gene ID: 153572 | Gene type: protein coding

About IRX2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:2,735,635-2,751,677 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 4.6), skin (RPKM 2.8) and 9 other tissues.

Summary

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

IRX2 Products(2)

mRNA	Protein	Name
NM_001134222.2	NP_001127694.1	iroquois-class homeodomain protein IRX-2
NM_033267.5	NP_150366.1	iroquois-class homeodomain protein IRX-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	26560478	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26560478	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX2 Protein Structure

Homeobox_KN

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-2

homeodomain protein IRXA2

IRX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IRX2	Q9BZI1	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	IRX2	Q9BZI1	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	IRX2	Q9BZI1	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	IRX2	Q9BZI1	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	IRX2	Q9BZI1	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	IRX2	Q9BZI1	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	IRX2	Q9BZI1	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Pilocytic Astrocytoma Of Cerebellum

Cerebellar Pilocytic Astrocytoma

Anthracosis

Black Lung	Coal Workers' Pneumoconiosis
Melanoedema	Black Lung Disease
Pneumoconiosis	Coal Miner'S Pneumoconiosis
Coal Workers' Lung	Coal Worker'S Pneumoconiosis
Coal Workers Pneumoconiosis	Coal Miners' Lung
Coal Miners' Pneumoconiosis	Coal Pneumoconiosis
Colliers' Anthracosis	Colliers' Lung
Lung Melanosis	Miners' Asthma
Miners' Lung	Pneumomelanosis
Cwp - [Coalworkers Pneumoconiosis]	Fibrosis Of Lung With Anthracosilicosis
Lung Fibrosis With Anthracosis	Miners' Pneumoconiosis
Carbon Lung	Coalworker Lung
Collier'S Asthma	Anthracosilicosis
Lung Anthracosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06921	IRX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRX2	MGD	MGI:1197526
Canis familiaris	IRX2	VGNC	VGNC:42101
Bos taurus	IRX2	VGNC	VGNC:54439
Rattus norvegicus	IRX2	RGD	RGD:1309834
Macaca mulatta	IRX2	VGNC	VGNC:73592
Felis catus	IRX2	VGNC	VGNC:102236

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