2. Gene
  3. TMEM74 - transmembrane protein 74 Gene

TMEM74 - transmembrane protein 74 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NET36

Gene ID: 157753 | Gene type: protein coding

About TMEM74

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,606,850-108,787,594 (from NCBI)

This gene has 2 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in brain (RPKM 1.7), heart (RPKM 0.4) and 6 other tissues.

Summary

Involved in macroautophagy. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM74 Products(1)

mRNA Protein Name
NM_153015.3 NP_694560.1 transmembrane protein 74
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
18294959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM74 Protein Structure

Neurensin

Neurensin: Neurensin (175 - 258)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

transmembrane protein 74

Related Diseases

Diseases Alias
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14741 TMEM74 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMEM74 MGD MGI:2443417
Macaca mulatta TMEM74 VGNC VGNC:79606
Felis catus TMEM74 VGNC VGNC:66362
Rattus norvegicus TMEM74 RGD RGD:1566279
Canis familiaris TMEM74 VGNC VGNC:47604
Bos taurus TMEM74 VGNC VGNC:36111