2. Gene
  3. CFAP58 - cilia and flagella associated protein 58 Gene

CFAP58 - cilia and flagella associated protein 58 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as SPGF49; CCDC147; C10orf80; bA127L20.4; bA127L20.5; bA554P13.1

Gene ID: 159686 | Gene type: protein coding

About CFAP58

Summary

Involved in protein localization to motile cilium; sperm axoneme assembly; and sperm mitochondrial sheath assembly. Located in sperm midpiece. Implicated in spermatogenic failure 49. [provided by Alliance of Genome Resources, Apr 2022]

CFAP58 Products(1)

mRNA Protein Name
NM_001008723.2 NP_001008723.1 cilia- and flagella-associated protein 58 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
32791035 GOA
involved in protein localization to motile cilium IMP
IMP: Inferred from mutant phenotype
32791035 GOA
involved in sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
32791035 GOA
involved in sperm mitochondrial sheath assembly IMP
IMP: Inferred from mutant phenotype
32791035 GOA
Cellular Component GO Annotation Evidence Reference Source
located in sperm flagellum IDA
IDA: Inferred from direct assay
33314088 GOA
located in sperm midpiece IMP
IMP: Inferred from mutant phenotype
32791035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cilia- and flagella-associated protein 58

coiled-coil domain containing 147

coiled-coil domain-containing protein 147

CFAP58 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CFAP58 Q5T655 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra
CFAP58 Q5T655 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra
CFAP58 Q5T655 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
CFAP58 Q5T655 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
CFAP58 Q5T655 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
CFAP58 Q5T655 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
CFAP58 Q5T655 MCC Homo sapiens P23508
Y2H Array
32296183
Intra
CFAP58 Q5T655 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra
CFAP58 Q5T655 NAV2 Homo sapiens Q8IVL1
Validated Y2H
25416956
Intra
CFAP58 Q5T655 NAV2 Homo sapiens Q8IVL1
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction