NAV2 - neuron navigator 2 Gene

Homo sapiens

Also known as HELAD1; RAINB1; POMFIL2; UNC53H2; STEERIN2

Gene ID: 89797 | Gene type: protein coding

About NAV2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,345,236-20,121,601 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 4.0), brain (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NAV2 Products(5)

mRNA	Protein	Name
NM_001111018.2	NP_001104488.1	neuron navigator 2 isoform 3
NM_001111019.3	NP_001104489.1	neuron navigator 2 isoform 4
NM_001244963.2	NP_001231892.1	neuron navigator 2 isoform 5
NM_145117.5	NP_660093.2	neuron navigator 2 isoform 2
NM_182964.6	NP_892009.3	neuron navigator 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' DNA helicase activity	IDA IDA: Inferred from direct assay	12214280	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAV2 Protein Structure

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2488 a.a.

Protein Preferred Names

Protein Names

neuron navigator 2

helicase, APC down-regulated 1

NAV2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NAV2	Q8IVL1	CFAP58	Homo sapiens	Q5T655	Y2H Array	25416956
Intra	NAV2	Q8IVL1	RBM15B	Homo sapiens	Q8NDT2-2	Y2H Array	25416956
Intra	NAV2	Q8IVL1	RBM15B	Homo sapiens	Q8NDT2-2	Y2H Prey Pooling	25416956
Intra	NAV2	Q8IVL1	RBM15	Homo sapiens	Q96T37	Y2H Array	25416956
Intra	NAV2	Q8IVL1	ADAT2	Homo sapiens	Q7Z6V5	Y2H Prey Pooling	25416956
Intra	NAV2	Q8IVL1	ADAT2	Homo sapiens	Q7Z6V5	Validated Y2H	25416956
Intra	NAV2	Q8IVL1	ADAT2	Homo sapiens	Q7Z6V5	Y2H Array	25416956
Intra	NAV2	Q8IVL1	ING4	Homo sapiens	Q9UNL4	Y2H Array	25416956
Intra	NAV2	Q8IVL1	ING4	Homo sapiens	Q9UNL4	Validated Y2H	25416956
Intra	NAV2	Q8IVL1	PIAS2	Homo sapiens	O75928	Y2H Array	25416956
Intra	NAV2	Q8IVL1	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	NAV2	Q8IVL1	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	NAV2	Q8IVL1	ING5	Homo sapiens	Q8WYH8	Validated Y2H	25416956
Intra	NAV2	Q8IVL1	RBM15B	Homo sapiens	Q8NDT2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuroblastoma 1

Neuroblastoma, Susceptibility To, 1	NBLST1
Neuroblastoma, Susceptibility To, Type 1

Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency	CSID
Si Deficiency	Congenital Sucrose Intolerance
Disaccharide Intolerance	Sucrase-Isomaltase Deficiency
Disaccharide Intolerance I	Congenital Sucrose-Isomaltose Malabsorption
Sucrose-Isomaltose Malabsorption, Congenital	Sucrose Intolerance, Congenital
Congenital Sucrase-Isomaltose Malabsorption	Congenital Sucrose-Isomaltase Malabsorption
Disaccharide Intolerance, 1	Sucrose Intolerance Congenital
Sucrose-Isomaltase Malabsorption, Congenital	Disaccharidase Deficiency
Invertase Deficiency	Sucrase-Alpha-Dextrinase Deficiency
Disaccharide Intolerance Type I	Csid - [Congenital Sucrase-Isomaltase Deficiency]
Sucrose Intolerance Of Newborn	Sucrose Intolerance
Sucrase Deficiency	Disaccharide Malabsorption
Intestinal Disaccharidase Deficiency

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09047	NAV2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NAV2	VGNC	VGNC:74968
Felis catus	NAV2	VGNC	VGNC:81976
Bos taurus	NAV2	VGNC	VGNC:31891
Mus musculus	NAV2	MGD	MGI:2183691
Canis familiaris	NAV2	VGNC	VGNC:43630
Rattus norvegicus	NAV2	RGD	RGD:619778

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