2. Immunology/Inflammation
  3. CD3
  4. Tepoditamab

Tepoditamab  (Synonyms: MCLA 117)

Cat. No.: HY-P99390 Purity: ≥99%
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Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab (MCLA-117) kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells and can be used in acute myeloid leukaemia (AML) research.

For research use only. We do not sell to patients.

CAS No. : 2044679-53-8

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Based on 1 publication(s) in Google Scholar

Tepoditamab Related Antibodies

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Description

Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab (MCLA-117) kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells and can be used in acute myeloid leukaemia (AML) research[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Bispecific

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tepoditamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.
Purity & Documentation
References
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Tepoditamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tepoditamab2044679-53-8MCLA 117MCLA117MCLA-117CD3Cluster of differentiation 3CLEC12AT cellAMLInhibitorinhibitorinhibit

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