1. Gene
  2. DAO - D-amino acid oxidase Gene

DAO - D-amino acid oxidase Gene

Homo sapiens

Also known as DAAO; OXDA; DAMOX

Gene ID: 1610 | Gene type: protein coding

About DAO

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,880,092-108,901,043 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1).

Summary

This gene encodes the peroxisomal Enzyme D-amino acid oxidase. The Enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA Receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

DAO Products(3)

mRNA Protein Name
NM_001413634.1 NP_001400563.1 D-amino-acid oxidase isoform a
NM_001413635.1 NP_001400564.1 D-amino-acid oxidase isoform b
NM_001917.5 NP_001908.3 D-amino-acid oxidase isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D-amino-acid oxidase activity IDA
IDA: Inferred from direct assay
12364586 GOA
enables D-amino-acid oxidase activity IMP
IMP: Inferred from mutant phenotype
29274788 GOA
enables FAD binding IDA
IDA: Inferred from direct assay
16616139 GOA
enables FAD binding IMP
IMP: Inferred from mutant phenotype
29274788 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16616139 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12364586 GOA
Biological Process GO Annotation Evidence Reference Source
involved in D-alanine catabolic process IDA
IDA: Inferred from direct assay
16616139 GOA
involved in D-amino acid catabolic process IDA
IDA: Inferred from direct assay
29274788 GOA
involved in D-serine catabolic process IDA
IDA: Inferred from direct assay
18544534 GOA
involved in D-serine metabolic process IDA
IDA: Inferred from direct assay
21679769 GOA
involved in dopamine biosynthetic process IDA
IDA: Inferred from direct assay
17303072 GOA
involved in proline catabolic process IDA
IDA: Inferred from direct assay
16616139 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17880399 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18544534 GOA
colocalizes with mitochondrial outer membrane IDA
IDA: Inferred from direct assay
21679769 GOA
located in peroxisomal matrix IDA
IDA: Inferred from direct assay
17684499 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAO Protein Structure

DAO

DAO: FAD dependent oxidoreductase (3 - 328)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

D-amino-acid oxidase

DAO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DAO P14920 PRKAB2 Homo sapiens O43741 25416956
Intra
DAO P14920 PRKAB2 Homo sapiens O43741 31515488
Intra
DAO P14920 KLHL42 Homo sapiens Q9P2K6 33961781
Intra
DAO P14920 KLHL42 Homo sapiens Q9P2K6 28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DAO Proteins

Cat. No. Product Name Accession Purity
HY-P7898 D-amino-acid oxidase/DAO Protein, Human (His) P14920 (M1-L347) ≥95%

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Aging
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis

Schizo-Affective Type Schizophrenia

Schizoaffective Psychosis

Schizoaffective Schizophrenia

Schizophrenia, Schizo-Affective Type

Schizophreniform Psychosis, Affective Type

Schizotypal Personality Disorder

Schizotypal Personality

Molybdenum Cofactor Deficiency, Complementation Group B

MOCODB

Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B

Molybdenum Cofactor Deficiency B

Molybdenum Cofactor Deficiency Type B

Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B

Mocod Type B

Molybdenum Cofactor Deficiency Complementation Group B

Deficiency, Molybdenum Cofactor, Complementation Group B

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris DAO VGNC VGNC:39768
Bos taurus DAO VGNC VGNC:27875
Macaca mulatta DAO VGNC VGNC:71729
Rattus norvegicus DAO RGD RGD:621138
Mus musculus DAO MGD MGI:94859
Felis catus DAO VGNC VGNC:61335
Others DAO NCBI