DAO - D-amino acid oxidase Gene

Homo sapiens

Also known as DAAO; OXDA; DAMOX

Gene ID: 1610 | Gene type: protein coding

About DAO

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,880,092-108,901,043 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1).

Summary

This gene encodes the peroxisomal Enzyme D-amino acid oxidase. The Enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA Receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

DAO Products(3)

mRNA	Protein	Name
NM_001413634.1	NP_001400563.1	D-amino-acid oxidase isoform a
NM_001413635.1	NP_001400564.1	D-amino-acid oxidase isoform b
NM_001917.5	NP_001908.3	D-amino-acid oxidase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-amino-acid oxidase activity	IDA IDA: Inferred from direct assay	12364586	GOA
enables D-amino-acid oxidase activity	IMP IMP: Inferred from mutant phenotype	29274788	GOA
enables FAD binding	IDA IDA: Inferred from direct assay	16616139	GOA
enables FAD binding	IMP IMP: Inferred from mutant phenotype	29274788	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16616139	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12364586	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-alanine catabolic process	IDA IDA: Inferred from direct assay	16616139	GOA
involved in D-amino acid catabolic process	IDA IDA: Inferred from direct assay	29274788	GOA
involved in D-serine catabolic process	IDA IDA: Inferred from direct assay	18544534	GOA
involved in D-serine metabolic process	IDA IDA: Inferred from direct assay	21679769	GOA
involved in dopamine biosynthetic process	IDA IDA: Inferred from direct assay	17303072	GOA
involved in proline catabolic process	IDA IDA: Inferred from direct assay	16616139	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17880399	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18544534	GOA
colocalizes with mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21679769	GOA
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	17684499	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAO Protein Structure

DAO

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

D-amino-acid oxidase

DAO Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DAO	P14920	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	DAO	P14920	PRKAB2	Homo sapiens	O43741	Y2H Array	31515488
Intra	DAO	P14920	KLHL42	Homo sapiens	Q9P2K6	Anti Tag CoIP	33961781
Intra	DAO	P14920	KLHL42	Homo sapiens	Q9P2K6	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DAO Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7898	D-amino-acid oxidase/DAO Protein, Human (His)	P14920 (M1-L347)	≥95%

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Aging

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Schizotypal Personality Disorder

Schizotypal Personality

Molybdenum Cofactor Deficiency, Complementation Group B

MOCODB	Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B
Molybdenum Cofactor Deficiency B	Molybdenum Cofactor Deficiency Type B
Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B	Mocod Type B
Molybdenum Cofactor Deficiency Complementation Group B	Deficiency, Molybdenum Cofactor, Complementation Group B

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2758	Diamine oxidase		/	Phase 4

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117292	DAO-IN-2	Inhibitor	99.83%	Unkown
HY-W037417	DAO-IN-1	Inhibitor	97.46%	Unkown
HY-15913	DAOS		99.88%	Unkown
HY-RS03523	DAO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W027382	SEP-227900		99.40%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DAO	VGNC	VGNC:39768
Bos taurus	DAO	VGNC	VGNC:27875
Macaca mulatta	DAO	VGNC	VGNC:71729
Rattus norvegicus	DAO	RGD	RGD:621138
Mus musculus	DAO	MGD	MGI:94859
Felis catus	DAO	VGNC	VGNC:61335
Others	DAO	NCBI

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