2. Gene
  3. DNAAF4 - dynein axonemal assembly factor 4 Gene

DNAAF4 - dynein axonemal assembly factor 4 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as RD; DYX1; EKN1; pf23; DYXC1; CILD25; DYX1C1

Gene ID: 161582 | Gene type: protein coding

About DNAAF4

Summary

This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, HSP70 and HSP90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]

DNAAF4 Products(1)

mRNA Protein Name
NM_001033560.2 NP_001028732.1 dynein axonemal assembly factor 4 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
19423554 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19423554 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cilium movement IMP
IMP: Inferred from mutant phenotype
23872636 GOA
involved in determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
23872636 GOA
involved in inner dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23872636 GOA
involved in outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23872636 GOA
involved in regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
19423554 GOA
involved in regulation of proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
19423554 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16989952 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16989952 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal assembly factor 4

dynein assembly factor 4, axonemal

dyslexia susceptibility 1 candidate 1

dyslexia susceptibility 1 candidate gene 1 protein

DNAAF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DNAAF4 Q8WXU2 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Intra
DNAAF4 Q8WXU2 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
DNAAF4 Q8WXU2 SPDL1 Homo sapiens Q96EA4
Validated Y2H
25416956
Intra
DNAAF4 Q8WXU2 SPDL1 Homo sapiens Q96EA4
Y2H Array
25416956
Intra
DNAAF4 Q8WXU2 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
DNAAF4 Q8WXU2 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction