SPDL1 - spindle apparatus coiled-coil protein 1 Gene

Homo sapiens

Also known as CCDC99

Gene ID: 54908 | Gene type: protein coding

About SPDL1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:169,583,773-169,604,778 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in testis (RPKM 14.1), lymph node (RPKM 4.5) and 21 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]

SPDL1 Products(6)

mRNA	Protein	Name
NM_001329639.2	NP_001316568.1	protein Spindly isoform a
NM_001329640.2	NP_001316569.1	protein Spindly isoform a
NM_001329641.2	NP_001316570.1	protein Spindly isoform b
NM_001329642.2	NP_001316571.1	protein Spindly isoform c
NM_001329643.2	NP_001316572.1	protein Spindly isoform d
NM_017785.5	NP_060255.3	protein Spindly isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables kinetochore binding	IDA IDA: Inferred from direct assay	19468067	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19468067	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	30258100	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	19468067	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19468067	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	19468067	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	19468067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Spindly

arsenite-related gene 1 protein

SPDL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPDL1	Q96EA4	RTP5	Homo sapiens	Q14D33	Y2H Prey Pooling	25416956
Intra	SPDL1	Q96EA4	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	SPDL1	Q96EA4	RTP5	Homo sapiens	Q14D33	Y2H Array	25416956
Intra	SPDL1	Q96EA4	USP15	Homo sapiens	Q9Y4E8	Y2H Prey Pooling	25416956
Intra	SPDL1	Q96EA4	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
Intra	SPDL1	Q96EA4	PPP1R18	Homo sapiens	Q6NYC8	Y2H Array	25416956
Intra	SPDL1	Q96EA4	DNAAF4	Homo sapiens	Q8WXU2	Y2H Prey Pooling	25416956
Intra	SPDL1	Q96EA4	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Postinflammatory Pulmonary Fibrosis

Post-Inflammatory Pulmonary Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13653	SPDL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPDL1	VGNC	VGNC:77992
Felis catus	SPDL1	VGNC	VGNC:97641
Rattus norvegicus	SPDL1	RGD	RGD:1306908
Canis familiaris	SPDL1	VGNC	VGNC:46727
Mus musculus	SPDL1	MGD	MGI:1917635
Bos taurus	SPDL1	VGNC	VGNC:50114

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