2. Gene
  3. Il12rb2 - interleukin 12 receptor, beta 2 Gene

Il12rb2 - interleukin 12 receptor, beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ifnm; IL-12RB2; A930027I18Rik

Gene ID: 16162 | Gene type: protein coding

About Il12rb2

Summary

Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Il12rb2 Products(2)

mRNA Protein Name
NM_001311141.1 NP_001298070.1 interleukin-12 receptor subunit beta-2 isoform 2
NM_008354.4 NP_032380.1 interleukin-12 receptor subunit beta-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17937931 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11489994 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
11489994 MGI
acts upstream of or within response to cytokine IMP
IMP: Inferred from mutant phenotype
11489994 MGI
acts upstream of or within response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
11489994 MGI
acts upstream of or within type II interferon production IGI
IGI: Inferred from genetic interaction
11489994 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15220916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-12 receptor subunit beta-2

IL-12 receptor subunit beta-2

IL-12R subunit beta-2

interferon response to microorganisms

Il12rb2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Il12rb2 P97378 Gak Mus musculus Q99KY4
Y2H
17937931
Intra
Il12rb2 P97378 Gak Mus musculus Q99KY4
Anti Tag CoIP
17937931
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il12rb2 Proteins

Cat. No. Product Name Accession Purity
HY-P72596 IL-12R beta 2 Protein, Mouse (HEK293, Fc) P97378 (N24-N637) ≥95%
HY-P74834 IL-12R beta 2 Protein, Mouse (HEK293, His) P97378 (N24-N637) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06684 IL12RB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990985 Efarindodekin alfa Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12rb2 NCBI NCBI:3595