2. Gene
  3. Gak - cyclin G associated kinase Gene

Gak - cyclin G associated kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D130045N16Rik

Gene ID: 231580 | Gene type: protein coding

About Gak

Chromosome 5: 108,717,277-108,777,621 reverse strand.GRCm39:CM000998.3

This gene has 13 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 7 phenotypes. Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues.

Summary

Predicted to enable clathrin binding activity and cyclin binding activity. Acts upstream of or within several processes, including animal organ development; clathrin coat disassembly; and positive regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in several structures, including central nervous system; liver; and retina. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gak Products(6)

mRNA Protein Name
NM_001359923.1 NP_001346852.1 cyclin-G-associated kinase isoform 5
NM_001282052.1 NP_001268981.1 cyclin-G-associated kinase isoform 3
NM_001359924.1 NP_001346853.1 cyclin-G-associated kinase isoform 2
NM_153569.2 NP_705797.1 cyclin-G-associated kinase isoform 1
NM_001282051.1 NP_001268980.1 cyclin-G-associated kinase isoform 2
NM_001359922.1 NP_001346851.1 cyclin-G-associated kinase isoform 4

Gak Protein Structure

STKc_GAK

STKc_GAK: cd14036 (38 - 319)

PTP_GAK

PTP_GAK: cd14564 (397 - 559)

PTEN_C2

PTEN_C2: pfam10409 (567 - 705)

PHA03247

PHA03247: cl33720 (712 - 1168)

DnaJ

DnaJ: cd06257 (1252 - 1297)

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  • 1305 a.a.
Protein Preferred Names Protein Names

cyclin-G-associated kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-122186 SGC-GAK-1 99.92% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-148063 DB0614 98.80% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 99.09% Unkown
HY-124793 GAK inhibitor 49 98.79% Unkown
HY-148061 DB1113 99.28% Unkown
HY-124793A GAK inhibitor 49 hydrochloride 99.52% Unkown
HY-120179A LP-922761 hydrate ≥98.0% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-101290 BMT-090605 Inhibitor / Unkown
HY-135871 BMT-124110 / Unkown
HY-147761 GAK inhibitor 2 Inhibitor / Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-RS05235 GAK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05236 Gak Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05237 Gak Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gak NCBI NCBI:2580
Macaca fascicularis Gak NCBI NCBI:102115623