Il15 - interleukin 15 Gene

Mus musculus

Also known as IL-15

Gene ID: 16168 | Gene type: protein coding

About Il15

Chromosome 8: 83,058,261-83,129,851 reverse strand.GRCm39:CM001001.3

This gene has 10 transcripts (splice variants), 128 orthologues and is associated with 42 phenotypes. Broad expression in heart adult (RPKM 5.2), duodenum adult (RPKM 3.3) and 24 other tissues.

Summary

This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against Bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]

Il15 Products(2)

mRNA	Protein	Name
NM_001254747.2	NP_001241676.1	interleukin-15 preproprotein
NM_008357.3	NP_032383.1	interleukin-15 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	14607906	MGI
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	10704459	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within NK T cell proliferation	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	17318811	MGI
acts upstream of or within extrathymic T cell selection	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of natural killer cell differentiation	IDA IDA: Inferred from direct assay	14607906	MGI
acts upstream of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	14607906	MGI
acts upstream of natural killer cell proliferation	IDA IDA: Inferred from direct assay	14607906	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27684068	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of or within positive regulation of immune response	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IDA IDA: Inferred from direct assay	14607906	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	17318811	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	14607906	MGI
acts upstream of or within positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	14607906	MGI
acts upstream of or within positive regulation of protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	24509081	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	10704459	MGI
acts upstream of or within regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	10704459	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11737071	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il15 Protein Structure

IL15

0
100
162 a.a.

Protein Preferred Names

Protein Names

interleukin-15

Recombinant Il15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78558	IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)	Q60819-1 (G33-K205) & P48346 (G30-S162)	≥95%
HY-P700193AF	Animal-Free IL-15 Protein, Mouse (His)	P48346 (N49-S162)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99661	Inbakicept	Activator	98.95%	Unkown

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99850	Depemokimab	Inhibitor	/	Phase 3
HY-P99410	Ordesekimab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15898	Y-320		99.74%	Unkown
HY-102049	IL-15-IN-1	Inhibitor	99.42%	Unkown
HY-Y0493	HODHBt	Inhibitor	99.93%	Unkown
HY-153050	JAK-IN-24	Inhibitor	99.27%	Unkown
HY-RS06690	IL15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06691	Il15 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06692	Il15 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06693	IL15RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990719	Efbalropendekin alfa		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il15	NCBI	NCBI:3600
Susscrofa domestica	Il15	NCBI
Macaca mulatta	Il15	NCBI	NCBI:699616

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