2. Immunology/Inflammation
  3. Interleukin Related
  4. Inbakicept

Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells.

For research use only. We do not sell to patients.

CAS No. : 2135939-52-3

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Inbakicept Related Antibodies

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Description

Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells[1].

Species

Human
IC50 & Target[1]

IL-15Rα

 

In Vitro

Inbakicept (0.01-1 nM; 20 hr) enhances human NK cell cytotoxicity and increases cytotoxic effector molecule expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Inbakicept Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Daudi, Raji, CD19+ FL cells
Concentration: 0.01 nM, 0.1 nM, and 1 nM
Incubation Time: 20 hours
Result: Increased the human NK cell cytotoxicity on Daudi, Raji, CD19+ FL cells.
In Vivo

Inbakicept (0.2 mg/kg; i.v.; twice weekly, for 2 weeks) enhances rituximab-directed protection from a lethal Daudi lymphoma challenge in mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with Daudi models[1]
Dosage: 0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, and 0.2 mg/kg
Administration: Intravenous injection; twice weekly, for 2 weeks
Result: Enhanced rituximab-directed control of Raji lymphoma challenge.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Inbakicept]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2-IGHG1 Fc (Fragment constant)
Biological Activity
  • Immobilized Human IL-15 Protein can bind Inbakicept. The EC50 for this effect is 50.78 ng/mL.
Purity & Documentation
References
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Inbakicept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inbakicept2135939-52-3Interleukin RelatedILInhibitorinhibitorinhibit

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