Il1r2 - interleukin 1 receptor, type II Gene

Mus musculus

Also known as CD121b; Il1r-2

Gene ID: 16178 | Gene type: protein coding

About Il1r2

Summary

Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including dorsal aorta; gut; pituitary gland; reproductive system; and thymus. Human ortholog(s) of this gene implicated in aggressive periodontitis. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Il1r2 Products(3)

mRNA	Protein	Name
NM_001360800.1	NP_001347729.1	interleukin-1 receptor type 2 isoform 1 precursor
NM_001360801.1	NP_001347730.1	interleukin-1 receptor type 2 isoform 3
NM_010555.5	NP_034685.1	interleukin-1 receptor type 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-1 binding	IPI IPI: Inferred from physical interaction	23395675	MGI
enables interleukin-1 receptor activity	IPI IPI: Inferred from physical interaction	23395675	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	23395675	MGI
acts upstream of or within negative regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	23395675	MGI
acts upstream of or within negative regulation of interleukin-1-mediated signaling pathway	IPI IPI: Inferred from physical interaction	23395675	MGI
acts upstream of or within negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	23395675	MGI
acts upstream of protein processing	IMP IMP: Inferred from mutant phenotype	23395675	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23395675	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor type 2

CD121 antigen-like family member B	IL-1 receptor beta chain
IL-1 type II receptor	IL-1R-2
IL-1R-beta	IL-1RT-2
IL-1RT2	interleukin-1 receptor beta

Recombinant Il1r2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72568	IL-1R2 Protein, Mouse (HEK293, His)	P27931 (F14-E355)	≥95%
HY-P74820	IL-1R2 Protein, Mouse (HEK293, hFc)	P27931 (F14-E355)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06721	IL1R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1r2	NCBI	NCBI:7850

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